Known targets — ChEMBL curated mechanism
PPARDPTGS1PTGS2dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Lysine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC1A5 | Q15758 | 5/20 | 0.46 |
| ▸ | EPOR | P19235 | 5/20 | 0.41 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.40 |
| ▸ | GRIK2 | Q13002 | 1/20 | 0.40 |
| ▸ | BACE1 | P56817 | 1/20 | 0.39 |
| ▸ | KIF11 | P52732 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | LTA4H | P09960 | 1/20 | 0.37 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.36 |
| ▸ | GSR | P00390 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Lysine SCHEMBL7802021 | 1.00 | SLC1A5 (0.46) | SLC1A5EPORGRIK1GRIK2BACE1 | |
| 2-(Aminomethyl)Phenol SCHEMBL8025682 | 0.90 | SLC1A5 (0.45) | SLC1A5EPORGRIK1GRIK2BACE1 | |
| 2-(Aminomethyl)Phenol SCHEMBL8025681 | 0.90 | SLC1A5 (0.45) | SLC1A5EPORGRIK1GRIK2BACE1 | |
| Lysine SCHEMBL7802098 | 0.89 | LTA4H (0.42) | SLC1A5EPORTDP1LTA4HEGLN2 | |
| Lysine SCHEMBL7802101 | 0.89 | LTA4H (0.42) | SLC1A5EPORTDP1LTA4HEGLN2 | |
| Lysine SCHEMBL7799061 | 0.89 | KMO (0.40) | SLC1A5EPORLTA4HEGLN2GSR | |
| Lysine SCHEMBL7799063 | 0.89 | KMO (0.40) | SLC1A5EPORLTA4HEGLN2GSR | |
| 2-(Aminomethyl)Phenol SCHEMBL7798293 | 0.86 | NPC1 (0.46) | SLC1A5EPORBACE1NPC1RAB9A | |
| Lysine SCHEMBL8039215 | 0.83 | GRIK1 (0.54) | SLC1A5GRIK1GRIK2KIF11NPC1 | |
| Lysine SCHEMBL8039212 | 0.83 | GRIK1 (0.54) | SLC1A5GRIK1GRIK2KIF11NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1076649-A1 | ISOQUINOLINE COMPOUND MELANOCORTIN RECEPTOR LIGANDS AND METHODS OF USING SAME | TREGA BIOSCIENCES, INC. (US) | 2001-02-21 | — | — | EP | disclosed |
| US-6127381-A | A MELANOCORTIN RECEPTOR LIGAND FOR REGULATING FOOD INTAKE AND BODY WEIGHT, REGULATING CYTOKINE ACTIVITY, ANTI-INFLAMMATORY ACTIVITY | LION BIOSCIENCE AG (DE) | 2000-10-03 | — | — | US | disclosed |
| WO-1999055679-A1 | ISOQUINOLINE COMPOUND MELANOCORTIN RECEPTOR LIGANDS AND METHODS OF USING SAME | TREGA BIOSCIENCES, INC. (US) | 1999-11-04 | — | — | WO | disclosed |