Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 3/20 | 0.58 |
| ▸ | LRRK2 | Q5S007 | 3/20 | 0.50 |
| ▸ | ULK1 | O75385 | 5/20 | 0.48 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.47 |
| ▸ | MAP4K1 | Q92918 | 2/20 | 0.45 |
| ▸ | KDR | P35968 | 3/20 | 0.44 |
| ▸ | AURKA | O14965 | 3/20 | 0.44 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.44 |
| ▸ | JAK2 | O60674 | 1/20 | 0.43 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.43 |
| ▸ | TYK2 | P29597 | 1/20 | 0.43 |
| ▸ | JAK3 | P52333 | 1/20 | 0.43 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.43 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.43 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7800595 | 0.84 | LRRK2 (0.46) | EGFRLRRK2ULK1PTK2AURKA | |
| SCHEMBL7791030 | 0.84 | FLT1 (0.55) | EGFRLRRK2PTK2MAP4K1KDR | |
| SCHEMBL7799232 | 0.82 | CSF1R (0.49) | EGFRLRRK2PTK2HTTSMN1; SMN2 | |
| SCHEMBL7800417 | 0.81 | LRRK2 (0.53) | EGFRLRRK2PTK2AURKAAURKB | |
| SCHEMBL1539121 | 0.81 | RET (0.55) | EGFRLRRK2KDRAURKAKMT2A | |
| SCHEMBL7790969 | 0.81 | EGFR (0.55) | EGFRLRRK2PTK2MAP4K1SMN1; SMN2 | |
| SCHEMBL7791014 | 0.81 | C1R (0.51) | EGFRLRRK2PTK2KMT2ASMN1; SMN2 | |
| SCHEMBL7799235 | 0.79 | CSF1R (0.52) | EGFRULK1MAP4K1KDRAURKA | |
| SCHEMBL7757002 | 0.78 | PDGFRB (0.59) | EGFRKDRAURKASMN1; SMN2 | |
| SCHEMBL15533894 | 0.78 | MAPK8 (0.55) | EGFRLRRK2ULK1MAP4K1ULK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1162974-A1 | QUINAZOLINE FORMULATIONS AND THERAPEUTIC USE THEREOF | Parker Hughes Institute (US) | 2001-12-19 | — | — | EP | disclosed |
| WO-2000056338-A1 | QUINAZOLINE FORMULATIONS AND THERAPEUTIC USE THEREOF | PARKER HUGHES INSTITUTE (US) | 2000-09-28 | — | — | WO | disclosed |