Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 3/20 | 0.38 |
| ▸ | WDR77 | Q9BQA1 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | GLS | O94925 | 2/20 | 0.34 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.34 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.34 |
| ▸ | PARP1 | P09874 | 1/20 | 0.33 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.33 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7809902 | 0.94 | PRMT5 (0.36) | PRMT5WDR77HPGDEPHX1USP30 | |
| SCHEMBL7806059 | 0.94 | PRMT5 (0.36) | PRMT5WDR77HPGDEPHX1USP30 | |
| SCHEMBL7808215 | 0.81 | PDE4A (0.37) | PRMT5WDR77ALDH1A1MEN1KMT2A | |
| SCHEMBL7808213 | 0.81 | PDE4A (0.37) | PRMT5WDR77ALDH1A1MEN1KMT2A | |
| SCHEMBL7804691 | 0.81 | PDE4A (0.37) | PRMT5WDR77ALDH1A1MEN1KMT2A | |
| SCHEMBL7804738 | 0.78 | PDE4A (0.38) | PRMT5WDR77ALDH1A1MEN1KMT2A | |
| SCHEMBL25042385 | 0.78 | MEN1 (0.48) | PRMT5WDR77ALDH1A1MEN1MAPT | |
| SCHEMBL7799295 | 0.77 | VHL (0.31) | PRMT5WDR77PARP1 | |
| SCHEMBL9595771 | 0.76 | NR1H2 (0.36) | ALDH1A1MEN1KMT2A | |
| SCHEMBL8107979 | 0.76 | NR1H2 (0.36) | ALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0773222-B1 | CARBAPENEM DERIVATIVE | EISAI CO LTD (JP) | 2001-10-04 | — | — | EP | disclosed |
| US-6037341-A | HAVING POTENT ANTIMICROBIAL EFFECTS OVER GRAM-POSITIVE BACTERIA AND GRAM-NEGATIVE BACTERIA | EISAI CO., LTD. (JP) | 2000-03-14 | — | — | US | disclosed |
| EP-0773222-A1 | NOVEL CARBAPENEM DERIVATIVE | Eisai Co., Ltd. (JP) | 1997-05-14 | — | — | EP | disclosed |