SCHEMBL7799316

SCHEMBL7799316

CC(C)(C)OC(=O)N1C[C@H](O[Si](C)(C)C(C)(C)C)C[C@H]1C(O)C1CN([Si](C)(C)C(C)(C)C)C1=O

nearest known ligand 0.32

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
HSD11B1 P28845 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7804738 0.84 PDE4A (0.38)
SCHEMBL7808215 0.83 PDE4A (0.37)
SCHEMBL7808213 0.83 PDE4A (0.37)
SCHEMBL7804691 0.83 PDE4A (0.37)
SCHEMBL7799295 0.83 VHL (0.31)
SCHEMBL7809902 0.78 PRMT5 (0.36)
SCHEMBL7806059 0.78 PRMT5 (0.36)
SCHEMBL9595771 0.76 NR1H2 (0.36)
SCHEMBL8107979 0.76 NR1H2 (0.36)
SCHEMBL8759135 0.76 NR1H2 (0.32)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0773222-B1 CARBAPENEM DERIVATIVE EISAI CO LTD (JP) 2001-10-04 EP disclosed
US-6037341-A HAVING POTENT ANTIMICROBIAL EFFECTS OVER GRAM-POSITIVE BACTERIA AND GRAM-NEGATIVE BACTERIA EISAI CO., LTD. (JP) 2000-03-14 US disclosed
EP-0773222-A1 NOVEL CARBAPENEM DERIVATIVE Eisai Co., Ltd. (JP) 1997-05-14 EP disclosed