Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 5/20 | 0.39 |
| ▸ | MEN1 | O00255 | 4/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.36 |
| ▸ | MTOR | P42345 | 2/20 | 0.36 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.36 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.36 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7804882 | 0.89 | HPGD (0.38) | HPGDMEN1KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL7806159 | 0.87 | ALDH1A1 (0.36) | HPGDMEN1KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL7809959 | 0.85 | SMN1; SMN2 (0.39) | KMT2AALDH1A1SMN1; SMN2LMNAMAPT | |
| SCHEMBL7806909 | 0.84 | ALDH1A1 (0.39) | HPGDMEN1KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL7809950 | 0.82 | PIK3CA (0.40) | ALDH1A1SMN1; SMN2LMNAMAPTPIK3CA | |
| SCHEMBL7806927 | 0.82 | HPGD (0.41) | HPGDMEN1KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL6563220 | 0.81 | HPGD (0.44) | HPGDMEN1KMT2AHSD17B10LMNA | |
| SCHEMBL7806152 | 0.81 | HRH3 (0.37) | ALDH1A1GAAHSD11B1L3MBTL1 | |
| SCHEMBL7804851 | 0.79 | HRH3 (0.36) | HSD11B1L3MBTL1 | |
| SCHEMBL7806160 | 0.78 | MEN1 (0.40) | MEN1KMT2AMAPTL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1140802-A1 | SUBSTITUTED ARYL AND HETEROARYL DERIVATIVES, THEIR PRODUCTION AND THEIR USE AS MEDICINES | BOEHRINGER INGELHEIM KG (DE) | 2001-10-10 | — | — | EP | disclosed |
| WO-2000035859-A1 | SUBSTITUTED ARYL AND HETEROARYL DERIVATIVES, THEIR PRODUCTION AND THEIR USE AS MEDICINES | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2000-06-22 | — | — | WO | disclosed |