Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2673952 | 0.87 | GABRA5 (0.49) | GABRA5 | |
| SCHEMBL15252292 | 0.85 | GABRA5 (0.51) | GABRA5GABRA1 | |
| SCHEMBL535960 | 0.85 | GABRA5 (0.78) | GABRA5 | |
| SCHEMBL2673947 | 0.85 | GABRA5 (0.58) | GABRA5GABRA1 | |
| SCHEMBL2673302 | 0.84 | GABRA5 (0.53) | GABRA5 | |
| SCHEMBL285833 | 0.84 | GABRA5 (0.56) | GABRA5GABRA1 | |
| SCHEMBL2673188 | 0.84 | GABRA5 (0.56) | GABRA5 | |
| SCHEMBL288078 | 0.81 | GABRA5 (0.54) | GABRA5GABRA1 | |
| SCHEMBL7521798 | 0.80 | GABRA5 (0.66) | GABRA5GABRA1 | |
| SCHEMBL535877 | 0.79 | GABRA5 (0.69) | GABRA5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8173652-B2 | Isoxazole-isoxazoles and isoxazole-isothiazoles | HOFFMANN-LA ROCHE INC. (US) | 2012-05-08 | — | — | US | disclosed |
| US-8173652-B2 | Isoxazole-isoxazoles and isoxazole-isothiazoles | HOFFMANN-LA ROCHE INC. (US) | 2012-05-08 | — | — | US | disclosed |
| US-20100210651-A1 | ISOXAZOLE-ISOXAZOLES AND ISOXAZOLE-ISOTHIAZOLES | ROCHE PALO ALTO LLC | 2010-08-19 | — | — | US | disclosed |
| US-20100210651-A1 | ISOXAZOLE-ISOXAZOLES AND ISOXAZOLE-ISOTHIAZOLES | ROCHE PALO ALTO LLC | 2010-08-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100210651-A1 | ISOXAZOLE-ISOXAZOLES AND ISOXAZOLE-ISOTHIAZOLES | GABRA5, GABRA1, GABRA4 | GABRA5 1/4885GABRA1 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.