Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 1/20 | 0.38 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.38 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.38 |
| ▸ | SCN5A | Q14524 | 3/20 | 0.36 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.36 |
| ▸ | KIF11 | P52732 | 1/20 | 0.36 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.36 |
| ▸ | GALR1 | P47211 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.35 |
| ▸ | GPR3 | P46089 | 1/20 | 0.35 |
| ▸ | CASP3 | P42574 | 1/20 | 0.35 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.34 |
| ▸ | AURKA | O14965 | 1/20 | 0.34 |
| ▸ | TPX2 | Q9ULW0 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5646728 | 0.74 | AHR (0.43) | ALOX5 | |
| SCHEMBL1967063 | 0.73 | NOTUM (0.34) | NOTUMEPHX2 | |
| SCHEMBL1135192 | 0.72 | — | — | |
| SCHEMBL6207069 | 0.72 | CYP2A6 (0.43) | CASP3MAPK1L3MBTL1 | |
| SCHEMBL3971470 | 0.71 | NOTUM (0.39) | NOTUMSCN5AFFAR1FFAR4KIF11 | |
| SCHEMBL17840231 | 0.70 | GPR3 (0.50) | NOTUMSCN5AFFAR1FFAR4KIF11 | |
| SCHEMBL454722 | 0.69 | AKR1C2 (0.42) | NOTUMAKR1C2AKR1C1SCN5AKIF11 | |
| SCHEMBL16720388 | 0.69 | AURKA (0.39) | NOTUMAKR1C2AKR1C1SCN5AFFAR1 | |
| SCHEMBL533257 | 0.69 | KIF11 (0.47) | NOTUMAKR1C2AKR1C1SCN5AKIF11 | |
| SCHEMBL6573034 | 0.69 | KIF11 (0.47) | NOTUMAKR1C2AKR1C1SCN5AKIF11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0535548-B1 | Inhibitor of atherosclerotic intimal thickening | NISSAN CHEMICAL IND LTD (JP) | 2001-11-21 | — | — | EP | claimed |