Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 1/20 | 0.39 |
| ▸ | GPR3 | P46089 | 2/20 | 0.38 |
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.38 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.38 |
| ▸ | KIF11 | P52732 | 1/20 | 0.37 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.37 |
| ▸ | SCN5A | Q14524 | 4/20 | 0.37 |
| ▸ | SERPINE1 | P05121 | 2/20 | 0.36 |
| ▸ | PRKDC | P78527 | 1/20 | 0.35 |
| ▸ | KIT | P10721 | 1/20 | 0.35 |
| ▸ | KDR | P35968 | 1/20 | 0.35 |
| ▸ | FLT3 | P36888 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.35 |
| ▸ | AURKA | O14965 | 1/20 | 0.35 |
| ▸ | TPX2 | Q9ULW0 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3540081 | 0.86 | METAP2 (0.37) | GPR3FFAR4FFAR1KIF11MAPT | |
| SCHEMBL6259560 | 0.85 | ABL1 (0.38) | FFAR4FFAR1KIF11AURKATPX2 | |
| SCHEMBL28839453 | 0.85 | SLC6A4 (0.34) | FFAR4MAPTKDM4EALDH1A1 | |
| SCHEMBL6190102 | 0.82 | ADORA1 (0.42) | GPR3 | |
| SCHEMBL6573031 | 0.81 | FFAR4 (0.40) | NOTUMGPR3FFAR4FFAR1KIF11 | |
| SCHEMBL17840231 | 0.79 | GPR3 (0.50) | NOTUMGPR3FFAR4FFAR1KIF11 | |
| SCHEMBL4280164 | 0.76 | PDK2 (0.45) | — | |
| SCHEMBL3289120 | 0.75 | HSD11B1 (0.41) | NOTUMALDH1A1 | |
| SCHEMBL7019991 | 0.75 | CYP2A6 (0.34) | GPR3NPC1RAB9A | |
| SCHEMBL15637646 | 0.75 | PDK2 (0.35) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7517901-B2 | p38 MAP kinase inhibitors and methods for using the same | ROCHE PALO ALTO LLC (US) | 2009-04-14 | — | — | US | claimed |
| EP-1919877-A1 | P38 MAP KINASE INHIBITORS AND METHODS FOR USING THE SAME | F.HOFFMANN-LA ROCHE AG (CH) | 2008-05-14 | — | — | EP | disclosed |
| WO-2007023114-A1 | P38 MAP KINASE INHIBITORS AND METHODS FOR USING THE SAME | F. HOFFMANN-LA ROCHE AG (CH) | 2007-03-01 | — | — | WO | disclosed |