Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | ITGAV | P06756 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.39 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7803961 | 0.81 | AGTR1 (0.51) | AGTR1AGTR2 | |
| SCHEMBL13026210 | 0.81 | ITGAV (0.42) | ALDH1A1ITGAVLMNASMN1; SMN2MEN1 | |
| SCHEMBL28618106 | 0.80 | LARS1 (0.55) | ALDH1A1TSHRLMNAKDM4ESMN1; SMN2 | |
| SCHEMBL15791260 | 0.72 | KMT2A (0.49) | ALDH1A1TSHRLMNASMN1; SMN2MEN1 | |
| SCHEMBL9860662 | 0.71 | ITGAV (0.48) | ALDH1A1TSHRITGAVLMNAAGTR1 | |
| SCHEMBL23852573 | 0.70 | MAOB (0.50) | ALDH1A1TSHRLMNAMAOBKDM4E | |
| SCHEMBL27021686 | 0.70 | NLRP3 (0.48) | ALDH1A1 | |
| SCHEMBL21098178 | 0.70 | CTDSP1 (0.43) | ALDH1A1SMN1; SMN2KMT2A | |
| SCHEMBL5640046 | 0.70 | SMN1; SMN2 (0.45) | ALDH1A1TSHRLMNAMAOBKDM4E | |
| SCHEMBL11851628 | 0.69 | GAA (0.49) | ALDH1A1TSHRITGAVLMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0749964-B1 | N-Heterocyclyl biphenyl sulfonamides | ASTRAZENECA AB (SE) | 2001-10-04 | — | — | EP | disclosed |
| EP-0749964-A1 | N-Heterocyclyl biphenyl sulfonamides | ZENECA LIMITED (GB) | 1996-12-27 | — | — | EP | disclosed |