Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSPO | P30536 | 1/20 | 0.64 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.59 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.59 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.59 |
| ▸ | HPGD | P15428 | 1/20 | 0.59 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.59 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.59 |
| ▸ | TACR1 | P25103 | 2/20 | 0.53 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.50 |
| ▸ | APOL1 | O14791 | 1/20 | 0.49 |
| ▸ | DRD2 | P14416 | 1/20 | 0.49 |
| ▸ | HTR2A | P28223 | 1/20 | 0.49 |
| ▸ | HTR2C | P28335 | 1/20 | 0.49 |
| ▸ | EGFR | P00533 | 1/20 | 0.48 |
| ▸ | SRC | P12931 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6926951 | 0.85 | TSPO (0.59) | TSPOKDM4EALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL7234870 | 0.83 | TSPO (0.61) | TSPOKDM4EALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL24907068 | 0.83 | APOL1 (0.68) | TACR1APOL1DRD2HTR2AHTR2C | |
| SCHEMBL7238028 | 0.81 | TSPO (0.58) | TSPOKDM4EALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL6928285 | 0.80 | TACR1 (0.55) | TSPOCYP1A2HPGDCYP2C19TACR1 | |
| SCHEMBL7233621 | 0.80 | TSPO (0.57) | TSPOKDM4EALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL7233607 | 0.79 | TSPO (0.59) | TSPOKDM4EALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL27587301 | 0.79 | TSPO (0.64) | TSPOKDM4EALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL7238513 | 0.79 | TSPO (0.56) | TSPOKDM4EALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL6922317 | 0.79 | PPARG (0.66) | TSPOKDM4EALDH1A1TACR1PDE10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20010039286-A1 | 2-aryl indole derivatives and their use as therapeutic agents | DINNELL KEVIN (GB) | 2001-11-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20010039286-A1 | 2-aryl indole derivatives and their use as therapeutic agents | IDO1, IDO2, CNR2 | TSPO 2379/4885KDM4E 2526/4885ALDH1A1 410/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.