Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 3/20 | 0.72 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | ALOX5 | P09917 | 4/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | RECQL | P46063 | 1/20 | 0.49 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.47 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | CA12 | O43570 | 1/20 | 0.47 |
| ▸ | CA9 | Q16790 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9707541 | 0.90 | RIPK1 (0.59) | RIPK1POLBALOX5MEN1KMT2A | |
| SCHEMBL25201520 | 0.85 | RIPK1 (0.55) | RIPK1POLBALOX5MEN1KMT2A | |
| SCHEMBL9707377 | 0.85 | ALOX5 (0.72) | RIPK1ALOX5PTGS1PTGS2L3MBTL1 | |
| SCHEMBL17874088 | 0.84 | RIPK1 (1.00) | RIPK1ALOX5NPC1RAB9A | |
| SCHEMBL28705761 | 0.82 | RECQL (0.58) | RIPK1POLBMEN1KMT2ACYP3A4 | |
| SCHEMBL17882238 | 0.82 | RIPK1 (0.64) | RIPK1POLBALOX5MEN1KMT2A | |
| SCHEMBL7616044 | 0.82 | RIPK1 (0.73) | RIPK1POLBALOX5MEN1KMT2A | |
| SCHEMBL23803517 | 0.82 | RIPK1 (0.64) | RIPK1POLBALOX5MEN1KMT2A | |
| SCHEMBL26154407 | 0.82 | RIPK1 (0.51) | RIPK1POLBALOX5MEN1KMT2A | |
| SCHEMBL23819836 | 0.81 | RIPK1 (0.62) | RIPK1POLBALOX5MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12129221-B2 | Difluoro phenyl amide RIP1 inhibitor | SIRONAX LTD (KY) | 2024-10-29 | — | — | US | disclosed |
| EP-3883918-B1 | RIP1 INHIBITORS | SIRONAX LTD (KY) | 2023-07-19 | — | — | EP | disclosed |
| CN-113272272-B | RIP1 inhibitors | 圣瑞诺有限公司 | 2023-04-07 | — | — | CN | disclosed |
| EP-3883918-A1 | RIP1 INHIBITORS | Sironax Ltd (KY) | 2021-09-29 | — | — | EP | disclosed |
| US-20210284598-A1 | RIP1 Inhibitors | SIRONAX LTD (KY) | 2021-09-16 | — | — | US | disclosed |
| US-20210284598-A1 | RIP1 Inhibitors | SIRONAX LTD (KY) | 2021-09-16 | — | — | US | disclosed |
| CN-113272272-A | RIP1 inhibitors | 圣瑞诺有限公司 | 2021-08-17 | — | — | CN | disclosed |
| EP-1143941-A3 | USE OF 3-ISOXAZOLIDINONES AND HYDROXYLAMINE ACIDS FOR THE TREATMENT OF INFECTIONS | Jomaa Pharmaka GmbH (DE) | 2002-02-06 | — | — | EP | disclosed |
| EP-1143941-A2 | USE OF 3-ISOXAZOLIDINONES AND HYDROXYLAMINE ACIDS FOR THE TREATMENT OF INFECTIONS | Jomaa Pharmaka GmbH (DE) | 2001-10-17 | — | — | EP | disclosed |
| WO-2000041473-A2 | USE OF 3-ISOXAZOLIDINONES AND HYDROXYLAMINE ACIDS FOR THE TREATMENT OF INFECTIONS | JOMAA PHARMAKA GMBH (DE) | 2000-07-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210284598-A1 | RIP1 Inhibitors | RIPK1, RIPK3, RIPK4 | RIPK1 1/4885POLB 3407/4885ALOX5 3090/4885 |
| US-12129221-B2 | Difluoro phenyl amide RIP1 inhibitor | RIPK1, RIPK3, RIPK4 | RIPK1 1/4885POLB 2576/4885ALOX5 3007/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.