Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 6/20 | 0.36 |
| ▸ | HPGD | P15428 | 5/20 | 0.36 |
| ▸ | TSHR | P16473 | 5/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.36 |
| ▸ | ATM | Q13315 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.36 |
| ▸ | CASP1 | P29466 | 1/20 | 0.36 |
| ▸ | CASP7 | P55210 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | CYP2A6 | P11509 | 4/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | TDP2 | O95551 | 1/20 | 0.32 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.32 |
| ▸ | CASP3 | P42574 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7853692 | 0.82 | ALDH1A1 (0.35) | HPGDL3MBTL1MAPK1RAB9AALDH1A1 | |
| Hydrochloric Acid SCHEMBL7807241 | 0.82 | HPGD (0.32) | HSD17B10HPGDTSHRL3MBTL1MAPK1 | |
| SCHEMBL7808023 | 0.79 | HPGD (0.35) | HSD17B10HPGDTSHRL3MBTL1MAPK1 | |
| Hydrochloric Acid SCHEMBL5951962 | 0.79 | HPGD (0.33) | HSD17B10HPGDTSHRL3MBTL1MAPK1 | |
| Hydrochloric Acid SCHEMBL8169167 | 0.78 | CNR1 (0.33) | L3MBTL1TDP1SLC6A4 | |
| Hydrochloric Acid SCHEMBL8606301 | 0.70 | DNMT1 (0.41) | HSD17B10HPGDTSHRL3MBTL1MAPK1 | |
| Hydrochloric Acid SCHEMBL4068158 | 0.70 | ALDH1A1 (0.37) | HPGDL3MBTL1MAPK1RAB9AALDH1A1 | |
| Hydrochloric Acid SCHEMBL4094233 | 0.70 | ALDH1A1 (0.37) | HPGDL3MBTL1MAPK1RAB9AALDH1A1 | |
| SCHEMBL25412675 | 0.70 | ALDH1A1 (0.62) | HSD17B10HPGDTSHRL3MBTL1MAPK1 | |
| SCHEMBL31171149 | 0.70 | ALDH1A1 (0.62) | HSD17B10HPGDTSHRL3MBTL1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20010007009-A1 | Transition metal catalyzed polymerization of olefinic monomers in a water-containing polymerization medium | BASF AKTIENGESELLSCHAFT (DE) | 2001-07-05 | — | — | US | disclosed |