Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 1/20 | 0.31 |
| ▸ | CNR1 | P21554 | 2/20 | 0.33 |
| ▸ | CNR2 | P34972 | 1/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.32 |
| ▸ | DRD2 | P14416 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | NCEH1 | Q6PIU2 | 1/20 | 0.31 |
| ▸ | BCHE | P06276 | 1/20 | 0.31 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7807241 | 0.88 | HPGD (0.32) | SLC6A4DRD2L3MBTL1 | |
| Hydrochloric Acid SCHEMBL8158885 | 0.82 | MEN1 (0.31) | BCHEACHE | |
| Hydrochloric Acid SCHEMBL5953226 | 0.82 | SLC6A4 (0.34) | CNR1CNR2SLC6A4DRD2BCHE | |
| Hydrochloric Acid SCHEMBL7800515 | 0.78 | HSD17B10 (0.36) | SLC6A4TDP1L3MBTL1 | |
| Hydrochloric Acid SCHEMBL3275850 | 0.76 | SLC6A4 (0.32) | SLC6A4DRD2 | |
| SCHEMBL7800533 | 0.72 | ALDH1A1 (0.32) | SLC6A4DRD2 | |
| Hydrochloric Acid SCHEMBL5951873 | 0.71 | SLC6A4 (0.34) | SLC6A4DRD2 | |
| Hydrochloric Acid SCHEMBL5688269 | 0.68 | CNR1 (0.37) | CNR1CNR2SLC6A4DRD2BCHE | |
| Hydrochloric Acid SCHEMBL8169170 | 0.68 | PSMB5 (0.32) | BCHE | |
| Hydrochloric Acid SCHEMBL5952974 | 0.67 | DRD2 (0.30) | SLC6A4DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0968158-A1 | METHOD OF PREPARING SUBSTITUTED INDANONES, THE SUBSTITUTED INDANONES AND METALLOCENES PREPARED THEREFROM | Basell Polyolefine GmbH (DE) | 2000-01-05 | — | — | EP | disclosed |
| WO-1998040331-A1 | PREPARATION OF PREPARING SUBSTITUTED INDANONES | TARGOR GMBH (DE) | 1998-09-17 | — | — | WO | disclosed |