Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 3/20 | 0.45 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.45 |
| ▸ | SLC10A2 | Q12908 | 1/20 | 0.45 |
| ▸ | DHFR | P00374 | 4/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.41 |
| ▸ | PDE4A | P27815 | 2/20 | 0.41 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | ACHE | P22303 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | FYN | P06241 | 1/20 | 0.40 |
| ▸ | DCPS | Q96C86 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6766348 | 0.87 | SLC10A2 (0.46) | ADORA2AADORA1SLC10A2PDE4BPDE4A | |
| SCHEMBL6772470 | 0.82 | SLC10A2 (0.45) | ADORA2AADORA1SLC10A2DHFRPDE4B | |
| SCHEMBL7794611 | 0.80 | ADORA2A (0.54) | ADORA2AADORA1SLC10A2DHFR | |
| SCHEMBL6765497 | 0.77 | SLC10A2 (0.45) | ADORA2AADORA1SLC10A2DHFRHSD17B10 | |
| SCHEMBL28041569 | 0.75 | SLC10A2 (0.56) | ADORA2AADORA1SLC10A2DHFRHSD17B10 | |
| SCHEMBL6767322 | 0.74 | SLC10A2 (0.46) | SLC10A2HSD17B10USP2POLBALDH1A1 | |
| SCHEMBL7015217 | 0.72 | PDGFRB (0.46) | SLC10A2HSD17B10ALDH1A1NPC1GAA | |
| SCHEMBL13975516 | 0.70 | DCPS (0.71) | ADORA2ADHFRACHEALDH1A1DCPS | |
| SCHEMBL27775603 | 0.70 | SLC10A2 (0.46) | ADORA2AADORA1SLC10A2DHFRHSD17B10 | |
| SCHEMBL5951260 | 0.70 | PDE4B (0.59) | PDE4BPDE4APDE4CPDE4DHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1163228-A1 | QUINAZOLINES AND THERAPEUTIC USE THEREOF | Parker Hughes Institute (US) | 2001-12-19 | — | — | EP | disclosed |
| WO-2000056720-A1 | QUINAZOLINES AND THERAPEUTIC USE THEREOF | PARKER HUGHES INSTITUTE (US) | 2000-09-28 | — | — | WO | disclosed |