Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARA | Q07869 | 4/20 | 0.70 |
| ▸ | PPARG | P37231 | 4/20 | 0.70 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.66 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.66 |
| ▸ | PPARD | Q03181 | 1/20 | 0.62 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.62 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.62 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.62 |
| ▸ | LTA4H | P09960 | 3/20 | 0.61 |
| ▸ | LAP3 | P28838 | 1/20 | 0.61 |
| ▸ | MAOB | P27338 | 2/20 | 0.59 |
| ▸ | LMNA | P02545 | 1/20 | 0.59 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.59 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.59 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.59 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.59 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.59 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.59 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.59 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15743318 | 0.95 | PPARG (0.65) | PPARAPPARGFFAR1FFAR4PPARD | |
| SCHEMBL14210013 | 0.95 | PPARA (0.68) | PPARAPPARGFFAR1FFAR4PPARD | |
| SCHEMBL6691879 | 0.89 | MAOB (0.62) | PPARAPPARGFFAR1FFAR4PPARD | |
| SCHEMBL1069493 | 0.87 | PPARG (0.67) | PPARAPPARGFFAR1FFAR4PPARD | |
| SCHEMBL287969 | 0.87 | PPARG (0.67) | PPARAPPARGFFAR1FFAR4PPARD | |
| SCHEMBL27654981 | 0.87 | NR4A2 (0.68) | PPARAPPARGNR4A1NR4A2NR4A3 | |
| SCHEMBL2164145 | 0.87 | PPARG (0.67) | PPARAPPARGFFAR1FFAR4PPARD | |
| SCHEMBL27385612 | 0.87 | LMNA (0.65) | PPARAPPARGFFAR1FFAR4PPARD | |
| SCHEMBL11308250 | 0.86 | PPARA (0.59) | PPARAPPARGFFAR1FFAR4PPARD | |
| SCHEMBL515522 | 0.85 | SLC7A5 (0.69) | PPARAPPARGFFAR1FFAR4PPARD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0721449-B1 | INHIBITORS OF BETA-AMYLOID PROTEIN PRODUCTION | MERRELL PHARMA INC (US) | 2001-12-19 | — | — | EP | disclosed |
| US-5977074-A | THERAPY FOR ALZHEIMER'S DISEASE | MERRELL PHARMACEUTICALS, INC. (US) | 1999-11-02 | — | — | US | disclosed |
| EP-0721449-A1 | INHIBITORS OF $g(b)-AMYLOID PROTEIN PRODUCTION | MERRELL PHARMACEUTICALS INC. (US) | 1996-07-17 | — | — | EP | disclosed |
| WO-1995009838-A1 | INHIBITORS OF β-AMYLOID PROTEIN PRODUCTION | MERRELL PHARMACEUTICALS INC. (US) | 1995-04-13 | — | — | WO | disclosed |
| EP-0361365-A1 | Aminobenzoic and aminocyclohexane-carboylic acid compounds, compositions, and their method of use | E.R. SQUIBB & SONS, INC. (US) | 1990-04-04 | — | — | EP | disclosed |