Sugi Predict

Sugi Predict / Compounds / SCHEMBL287969

SCHEMBL287969

SCHEMBL287969

O=C(O)C(O)Cc1ccc(OCc2ccccc2)cc1

nearest known ligand 0.67

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ PPARG P37231 5/20 0.67
▸ PPARA Q07869 4/20 0.67
▸ FFAR1 O14842 2/20 0.62
▸ FFAR4 Q5NUL3 1/20 0.62
▸ LTA4H P09960 3/20 0.62
▸ LAP3 P28838 1/20 0.62
▸ PPARD Q03181 1/20 0.59
▸ NR4A1 P22736 1/20 0.58
▸ NR4A2 P43354 1/20 0.58
▸ NR4A3 Q92570 1/20 0.58
▸ MAOB P27338 2/20 0.57
▸ LMNA P02545 1/20 0.56
▸ CYP1A2 P05177 1/20 0.56
▸ PTGS1 P23219 1/20 0.56
▸ SLC6A2 P23975 1/20 0.56
▸ CYP2C19 P33261 1/20 0.56
▸ PTGS2 P35354 1/20 0.56
▸ SLC6A3 Q01959 1/20 0.56
▸ HIF1A Q16665 1/20 0.56
▸ HDAC6 Q9UBN7 1/20 0.56

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1069493 1.00 PPARG (0.67) PPARGPPARAFFAR1FFAR4LTA4H
SCHEMBL2164145 1.00 PPARG (0.67) PPARGPPARAFFAR1FFAR4LTA4H
SCHEMBL14501335 0.88 MAOB (0.60) PPARGPPARAFFAR1FFAR4LTA4H
SCHEMBL27854776 0.88 LTA4H (0.71) PPARGPPARAFFAR1FFAR4LTA4H
SCHEMBL4756304 0.87 PPARG (0.57) PPARGPPARAFFAR1FFAR4LTA4H
SCHEMBL7801265 0.87 PPARA (0.70) PPARGPPARAFFAR1FFAR4LTA4H
SCHEMBL5309375 0.85 LTA4H (0.72) PPARGPPARAFFAR1FFAR4LTA4H
SCHEMBL10272384 0.85 ALOX5 (0.58) PPARGPPARAFFAR1FFAR4LTA4H
SCHEMBL6732617 0.85 LTA4H (0.72) PPARGPPARAFFAR1FFAR4LTA4H
SCHEMBL2164928 0.85 LTA4H (0.72) PPARGPPARAFFAR1FFAR4LTA4H

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 78 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12168648-B2 Opioid receptor modulators EPIODYNE, INC. (US) 2024-12-17 — — US disclosed
US-20240092746-A1 OPIOID RECEPTOR MODULATORS EPIODYNE, INC. 2024-03-21 — — US disclosed
EP-4320105-A1 OPIOID RECEPTOR MODULATORS Epiodyne, Inc. (US) 2024-02-14 — — EP disclosed
CN-117425644-A Opioid receptor modulators 埃皮欧黛公司 2024-01-19 — — CN disclosed
US-11634396-B2 Opioid receptor modulators EPIODYNE, INC. (US) 2023-04-25 — — US disclosed
US-20220356157-A1 OPIOID RECEPTOR MODULATORS NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2022-11-10 — — US disclosed
WO-2022216750-A1 OPIOID RECEPTOR MODULATORS EPIODYNE, INC. (US) 2022-10-13 — — WO disclosed
EP-3004053-B1 A PROCESS FOR PREPARATION OF PYRROLES HAVING HYPOLIPIDEMIC HYPOCHOLESTEREMIC ACTIVITIES CADILA HEALTHCARE LTD (IN) 2021-03-24 — — EP disclosed
US-10435363-B2 Process for preparation of pyrroles having hypolipidemic hypocholesteremic activities CADILA HEALTHCARE LIMITED (IN) 2019-10-08 — — US disclosed
EP-2427451-B1 ALPHA HELIX MIMETICS AND METHODS RELATING THERETO PRISM BIOLAB CO LTD (JP) 2019-03-20 — — EP disclosed
WO-2003008362-A1 NOVEL 3-ARYL-2-HYDROXY PROPANOL DERIVATIVES AND A PROCESS FOR THEIR PREPARATION DR. REDDY'S LABORATORIES LTD (IN) 2003-01-30 — — WO disclosed
WO-2003002575-A1 3-ARYL-$G(a)-OXY SUBSTITUTED PROPANOIC ACIDS AND A PROCESS FOR THEIR PREPARATION DR. REDDY'S LABORATORIES LTD. (IN) 2003-01-09 — — WO disclosed
WO-2003002550-A1 DIOXALANE DERIVATIVES AND A PROCESS FOR THEIR PREPARATION DR. REDDY'S RESEARCH FOUNDATION (IN) 2003-01-09 — — WO disclosed
WO-2002100813-A2 MODULATORS OF PEROXISOME PROLIFERATOR ACTIVATED RECEPTORS ELI LILLY AND COMPANY (US) 2002-12-19 — — WO disclosed
US-20020177726-A1 Process for the preparation of 3-aryl-2-hydroxy propanoic acid DR. REDDY'S RESEARCH FOUNDATION 2002-11-28 — — US disclosed
EP-1124808-A1 AN IMPROVED PROCESS FOR THE PREPARATION OF NEW ANTIDIABETIC AGENTS DR. REDDY'S RESEARCH FOUNDATION (IN) 2001-08-22 — — EP disclosed
WO-2000026200-A1 AN IMPROVED PROCESS FOR THE PREPARATION OF NEW ANTIDIABETIC AGENTS DR. REDDY'S RESEARCH FOUNDATION (IN) 2000-05-11 — — WO disclosed
US-5391565-A Hypoglycemic agents; antilipemic agents; hypotensive agents BEECHAN GROUP P.L.C. (GB) 1995-02-21 — — US disclosed
EP-0542816-A1 OXAZOLIDINE DIONE DERIVATIVES BEECHAM GROUP plc (GB) 1993-05-26 — — EP disclosed
WO-1992002520-A1 OXAZOLIDINE DIONE DERIVATIVES BEECHAM GROUP P.L.C. (GB) 1992-02-20 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240092746-A1 OPIOID RECEPTOR MODULATORS OPRM1, OPRK1, OPRL1 PPARG 395/4885PPARA 506/4885FFAR1 235/4885
US-12168648-B2 Opioid receptor modulators OPRM1, OPRK1, OPRL1 PPARG 395/4885PPARA 506/4885FFAR1 235/4885
US-11634396-B2 Opioid receptor modulators OPRM1, OPRK1, OPRL1 PPARG 395/4885PPARA 506/4885FFAR1 235/4885
US-20220356157-A1 OPIOID RECEPTOR MODULATORS OPRM1, OPRK1, OPRL1 PPARG 395/4885PPARA 506/4885FFAR1 235/4885
US-20020177726-A1 Process for the preparation of 3-aryl-2-hydroxy propanoic acid HPD, HAO1, HAAO PPARG 772/4885PPARA 265/4885FFAR1 75/4885
US-10435363-B2 Process for preparation of pyrroles having hypolipidemic hypocholesteremic activities CYP51A1, LIPA, DHCR7 PPARG 678/4885PPARA 418/4885FFAR1 959/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.