Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBXAS1 | P24557 | 2/20 | 0.43 |
| ▸ | AKR1C3 | P42330 | 4/20 | 0.42 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.38 |
| ▸ | TMPRSS15 | P98073 | 1/20 | 0.38 |
| ▸ | APEX1 | P27695 | 8/20 | 0.36 |
| ▸ | LOX | P28300 | 1/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.33 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.33 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2922217 | 0.75 | MAPT (0.49) | TBXAS1AKR1C3PRSS1TMPRSS15APEX1 | |
| SCHEMBL2922214 | 0.75 | MAPT (0.49) | TBXAS1AKR1C3PRSS1TMPRSS15APEX1 | |
| SCHEMBL29088426 | 0.72 | KDM4E (0.47) | TBXAS1AKR1C3PRSS1TMPRSS15POLB | |
| SCHEMBL7799437 | 0.71 | PKM (0.49) | TBXAS1AKR1C3PRSS1TMPRSS15APEX1 | |
| SCHEMBL29088392 | 0.70 | PRSS1 (0.41) | TBXAS1AKR1C3PRSS1TMPRSS15APEX1 | |
| SCHEMBL27845900 | 0.69 | LOX (0.43) | LOXALDH1A1 | |
| SCHEMBL3465940 | 0.69 | LOX (0.41) | LOXALDH1A1 | |
| SCHEMBL19436416 | 0.69 | LOX (0.57) | LOX | |
| SCHEMBL322182 | 0.67 | DAO (0.52) | LOXPOLBALDH1A1 | |
| SCHEMBL15836205 | 0.67 | LMNA (0.47) | LOXALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0790245-B1 | Substituted Thiophenylalkenylcarbonylguanidide, method for their preparation, their use as medicinal or diagnostic agent as well as medicament containing them | HOECHST AG (DE) | 2001-06-13 | — | — | EP | claimed |