Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | LIG1 | P18858 | 1/20 | 0.49 |
| ▸ | TBXAS1 | P24557 | 2/20 | 0.44 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.43 |
| ▸ | APEX1 | P27695 | 8/20 | 0.41 |
| ▸ | PLAU | P00749 | 1/20 | 0.37 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.36 |
| ▸ | TMPRSS15 | P98073 | 1/20 | 0.36 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2922217 | 0.77 | MAPT (0.49) | PKMTBXAS1AKR1C3APEX1PRSS1 | |
| SCHEMBL2922214 | 0.77 | MAPT (0.49) | PKMTBXAS1AKR1C3APEX1PRSS1 | |
| SCHEMBL9436131 | 0.71 | KMT2A (0.42) | PKMLIG1APEX1PLAUERBB2 | |
| SCHEMBL7801317 | 0.71 | TBXAS1 (0.43) | TBXAS1AKR1C3APEX1PRSS1TMPRSS15 | |
| SCHEMBL29088426 | 0.70 | KDM4E (0.47) | TBXAS1AKR1C3PRSS1TMPRSS15HTT | |
| SCHEMBL29088392 | 0.68 | PRSS1 (0.41) | TBXAS1AKR1C3APEX1PRSS1TMPRSS15 | |
| SCHEMBL29088472 | 0.68 | TBXAS1 (0.43) | TBXAS1AKR1C3APEX1PRSS1TMPRSS15 | |
| SCHEMBL4607795 | 0.67 | DAO (0.41) | TBXAS1AKR1C3HTTALDH1A1MAPT | |
| SCHEMBL4607793 | 0.67 | DAO (0.41) | TBXAS1AKR1C3HTTALDH1A1MAPT | |
| SCHEMBL9373389 | 0.66 | PKM (0.70) | PKMLIG1PLAUALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0790245-B1 | Substituted Thiophenylalkenylcarbonylguanidide, method for their preparation, their use as medicinal or diagnostic agent as well as medicament containing them | HOECHST AG (DE) | 2001-06-13 | — | — | EP | claimed |