Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 4/20 | 0.51 |
| ▸ | MAOB | P27338 | 9/20 | 0.46 |
| ▸ | RHOC | P08134 | 2/20 | 0.40 |
| ▸ | RHOA | P61586 | 2/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.40 |
| ▸ | CNR1 | P21554 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | PNMT | P11086 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Benzoic Acid SCHEMBL7798267 | 0.88 | TAAR1 (0.40) | TAAR1MAOBRHOCRHOA | |
| Tyramine SCHEMBL8035697 | 0.86 | TAAR1 (0.51) | TAAR1MAOB | |
| SCHEMBL7798427 | 0.85 | SRD5A2 (0.40) | TAAR1RHOCRHOALMNAPOLB | |
| 4-Methylbenzoic Acid SCHEMBL7792518 | 0.85 | SCN5A (0.40) | TAAR1RHOCRHOALMNAPOLB | |
| Phenethylamine SCHEMBL7801605 | 0.85 | TAAR1 (0.53) | TAAR1MAOB | |
| SCHEMBL7792354 | 0.85 | TAAR1 (0.58) | TAAR1MAOBRHOCRHOAPNMT | |
| SCHEMBL7802656 | 0.84 | RXRA (0.47) | MAOBLMNAPOLBMAPT | |
| SCHEMBL7801502 | 0.82 | TAAR1 (0.55) | TAAR1MAOB | |
| SCHEMBL18002359 | 0.81 | RHOC (0.43) | RHOCRHOAKCNH2TMEM97CNR1 | |
| SCHEMBL7801557 | 0.80 | MAOB (0.51) | TAAR1MAOBLMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1076649-A1 | ISOQUINOLINE COMPOUND MELANOCORTIN RECEPTOR LIGANDS AND METHODS OF USING SAME | TREGA BIOSCIENCES, INC. (US) | 2001-02-21 | — | — | EP | disclosed |
| US-6127381-A | A MELANOCORTIN RECEPTOR LIGAND FOR REGULATING FOOD INTAKE AND BODY WEIGHT, REGULATING CYTOKINE ACTIVITY, ANTI-INFLAMMATORY ACTIVITY | LION BIOSCIENCE AG (DE) | 2000-10-03 | — | — | US | disclosed |
| WO-1999055679-A1 | ISOQUINOLINE COMPOUND MELANOCORTIN RECEPTOR LIGANDS AND METHODS OF USING SAME | TREGA BIOSCIENCES, INC. (US) | 1999-11-04 | — | — | WO | disclosed |