Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | MIF | P14174 | 1/20 | 0.41 |
| ▸ | TYR | P14679 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.35 |
| ▸ | NQO2 | P16083 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | F12 | P00748 | 1/20 | 0.31 |
| ▸ | KCNJ11 | Q14654 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | ATP2A2 | P16615 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9322852 | 0.81 | PLAU (0.33) | — | |
| SCHEMBL9320794 | 0.78 | ALDH1A1 (0.33) | ALDH1A1 | |
| SCHEMBL9320813 | 0.76 | PTGS1 (0.43) | ALDH1A1LMNAHSD17B10GAAKDM4E | |
| SCHEMBL1415048 | 0.74 | LMNA (0.34) | ALDH1A1LMNANR1I2KDM4EMAPT | |
| SCHEMBL1680164 | 0.73 | NR1I2 (0.31) | NR1I2 | |
| SCHEMBL28898073 | 0.72 | ALDH1A1 (0.46) | ALDH1A1ALOX15LMNATYRHSD17B10 | |
| SCHEMBL26522334 | 0.69 | MCL1 (0.53) | ALDH1A1ALOX15LMNANR1I2CYP2C9 | |
| SCHEMBL2160202 | 0.65 | ALDH1A1 (0.70) | ALDH1A1ALOX15LMNANR1I2CYP2C9 | |
| SCHEMBL2043544 | 0.65 | LMNA (0.47) | ALDH1A1ALOX15LMNANR1I2CYP2C9 | |
| SCHEMBL7622508 | 0.65 | PDE4B (0.40) | ALDH1A1ALOX15LMNANR1I2CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0775133-B1 | NAPHTHALENE AMIDES HAVING LEUKOTRIENE-ANTAGONISTIC ACTION | MENARINI LAB (ES) | 2001-05-30 | — | — | EP | disclosed |
| WO-1996004267-A1 | NAPHTHALENE AMIDES HAVING LEUKOTRIENE-ANTAGONISTIC ACTION | LABORATORIOS MENARINI S.A. (ES) | 1996-02-15 | — | — | WO | disclosed |
| EP-0579731-A1 | DISUBSTITUTED NAPHTHALENES | SMITHKLINE BEECHAM CORPORATION (US) | 1994-01-26 | — | — | EP | disclosed |
| EP-0579731-A4 | DISUBSTITUTED NAPHTHALENES. | SMITHKLINE BEECHAM CORP (US) | 1993-12-07 | — | — | EP | disclosed |
| WO-1992017172-A1 | DISUBSTITUTED NAPHTHALENES | SMITHKLINE BEECHAM CORPORATION (US) | 1992-10-15 | — | — | WO | disclosed |