SCHEMBL7622508

SCHEMBL7622508

C[SiH](C)Oc1c(C(C)(C)C)ccc(O)c1-c1ccccc1

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PDE4B Q07343 6/20 0.40
PDE4A P27815 5/20 0.40
PDE4C Q08493 5/20 0.40
PDE4D Q08499 5/20 0.40
ALDH1A1 P00352 2/20 0.38
TSHR P16473 1/20 0.38
TDP1 Q9NUW8 1/20 0.38
ESRRA P11474 1/20 0.33
PKM P14618 2/20 0.33
HKDC1 Q2TB90 1/20 0.33
L3MBTL1 Q9Y468 1/20 0.33
CYP2C9 P11712 2/20 0.33
NR1I2 O75469 1/20 0.33
LMNA P02545 1/20 0.33
MIF P14174 1/20 0.33
TYR P14679 1/20 0.33
ALOX15 P16050 1/20 0.33
HTT P42858 1/20 0.33
NFE2L2 Q16236 1/20 0.33
HSD17B10 Q99714 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7702950 0.77 ALDH1A1 (0.48) PDE4BPDE4APDE4CPDE4DALDH1A1
Benzene SCHEMBL16500004 0.75 CA2 (0.48) PDE4BPDE4APDE4CPDE4DALDH1A1
SCHEMBL9235789 0.74 ALDH1A1 (0.45) PDE4BPDE4APDE4CPDE4DALDH1A1
SCHEMBL7236145 0.73 CASP1 (0.34) PDE4BPDE4APDE4CPDE4D
Phosphoric Acid SCHEMBL28336766 0.70 PTPN5 (0.42) PDE4BPDE4APDE4CPDE4DALDH1A1
SCHEMBL2497618 0.70 ALDH1A1 (0.59) PDE4BPDE4APDE4CPDE4DALDH1A1
SCHEMBL11776875 0.69 PDE4B (0.64) PDE4BPDE4APDE4CPDE4DALDH1A1
SCHEMBL8675813 0.69 NPC1 (0.41) ALDH1A1TSHRTDP1L3MBTL1CYP2C9
SCHEMBL9817074 0.68 CA2 (0.52) PDE4BPDE4APDE4CPDE4DALDH1A1
SCHEMBL5707884 0.68 ESR2 (0.42) PDE4BPDE4APDE4CPDE4DALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6441020-B1 INDOLACTAM DERIVATIVE ANTIINFLAMMATORY AGENTS PROCYON PHARMACEUTICALS, INC. 2002-08-27 US disclosed
US-6043270-A ANTIINFLAMMATORY AGENTS PROCYON PHARMACEUTICALS, INC. (US) 2000-03-28 US disclosed
US-5962498-A Protein kinase C modulators. C. indolactam structural-types with anti-inflammatory activity PROCYON PHARMACEUTICALS, INC. (US) 1999-10-05 US disclosed
EP-0553107-B1 PROTEIN KINASE C MODULATORS WITH ANTI-INFLAMMATORY AND ANTIVIRAL ACTIVITY PROCYON PHARM INC (US) 1999-09-29 EP disclosed
US-5891870-A ANTIINFLAMMATORY AGENTS USING BENZODITERPENES AND BENZOLACTAMS PROCYON PHARMACEUTICALS, INC. (US) 1999-04-06 US disclosed
US-5891906-A Polyacetate-derived phorboids having anti-inflammatory and other uses PROCYON PHARMACEUTICALS, INC. (US) 1999-04-06 US disclosed
US-5886019-A REPLACEMENT OF HYDROXYMETHYL OR-ETHYL GROUP ON TRICYCLIC AROMATIC HETEROCYCLIC COMPOUNDS HAVING INDOLE, INDENE, BENZOFURAN OR BENZOTHIOPHENE SKELETON; ANTIINFLAMMATORY, ANTIVIRAL PROCYON PHARMACEUTICALS, INC. (US) 1999-03-23 US disclosed
US-5750568-A DITERPENE PHORBOIDS PROCYON PHARMACEUTICALS, INC. (US) 1998-05-12 US disclosed
US-5716968-A ANTIINFLAMMATORY AGENTS; VIRICIDE PROCYON PHARMACEUTICALS, INC. (US) 1998-02-10 US disclosed
US-5643948-A ANTIINFLAMMATORY, ANTICANCER PROCYON PHARMACEUTICALS, INC. (US) 1997-07-01 US disclosed
WO-1997015575-A1 PROTEIN KINASE C MODULATORS. Y. PROCYON PHARMACEUTICALS, INC. (US) 1997-05-01 WO disclosed
EP-0553107-A1 PROTEIN KINASE C MODULATORS WITH ANTI-INFLAMMATORY AND ANTIVIRAL ACTIVITY PROCYON PHARMACEUTICALS, INC. (US) 1993-08-04 EP disclosed
WO-1992002484-A1 PROTEIN KINASE C MODULATORS WITH ANTI-INFLAMMATORY AND ANTIVIRAL ACTIVITY ALDER RESEARCH CENTER LIMITED PARTNERSHIP (US) 1992-02-20 WO disclosed