SCHEMBL7801883

SCHEMBL7801883

O=C(CN1CCNCC1)Nc1c(Cl)cc([N+](=O)[O-])cc1Cl

nearest known ligand 0.53

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
NPC1 O15118 1/20 0.53
RAB9A P51151 1/20 0.53
ALDH1A1 P00352 7/20 0.49
LMNA P02545 2/20 0.48
GAA P10253 2/20 0.47
MAPT P10636 2/20 0.47
KDM4E B2RXH2 1/20 0.47
GFER P55789 1/20 0.47
MCL1 Q07820 1/20 0.47
CYP2D6 P10635 2/20 0.46
CYP2C19 P33261 2/20 0.46
CYP1A2 P05177 1/20 0.46
RECQL P46063 1/20 0.46
CYP2C9 P11712 1/20 0.43
L3MBTL1 Q9Y468 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL7519848 0.99 NPC1 (0.52) NPC1RAB9AALDH1A1LMNAGAA
SCHEMBL7806812 0.84 RAB9A (0.74) NPC1RAB9AALDH1A1MAPTKDM4E
SCHEMBL8558093 0.83 NPC1 (0.51) NPC1RAB9AALDH1A1LMNAGAA
SCHEMBL9031073 0.80 NPC1 (0.56) NPC1RAB9AALDH1A1MAPTKDM4E
SCHEMBL7813743 0.80 RAB9A (0.56) NPC1RAB9AALDH1A1MAPTKDM4E
SCHEMBL7289700 0.79 KDM4E (0.62) NPC1RAB9AALDH1A1LMNAMAPT
SCHEMBL8553179 0.78 ALDH1A1 (0.53) NPC1RAB9AALDH1A1LMNAGAA
Hydrochloric Acid SCHEMBL7525895 0.78 KDM4E (0.61) NPC1RAB9AALDH1A1LMNAMAPT
SCHEMBL7289611 0.75 CHRM5 (0.50) NPC1RAB9AALDH1A1MAPTKDM4E
SCHEMBL9825041 0.75 ALDH1A1 (0.48) NPC1RAB9AALDH1A1LMNAMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0727421-B1 Agents for improving sleep JANSSEN PHARMACEUTICA NV (BE) 2001-10-24 EP disclosed
EP-0727421-A1 Agents for improving sleep JANSSEN PHARMACEUTICA N.V. (BE) 1996-08-21 EP disclosed
EP-0285219-A2 Method of improving sleep JANSSEN PHARMACEUTICA N.V. (BE) 1988-10-05 EP disclosed