Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 11/20 | 0.44 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.34 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.34 |
| ▸ | LRRK2 | Q5S007 | 3/20 | 0.32 |
| ▸ | HTR7 | P34969 | 1/20 | 0.31 |
| ▸ | MAOA | P21397 | 1/20 | 0.30 |
| ▸ | MAOB | P27338 | 1/20 | 0.30 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7816757 | 0.75 | ALOX5 (0.49) | ALOX5 | |
| SCHEMBL7813258 | 0.75 | ALOX5 (0.45) | ALOX5ADORA1LRRK2ADORA2A | |
| SCHEMBL7812869 | 0.75 | ALOX5 (0.45) | ALOX5ADORA1LRRK2ADORA2A | |
| SCHEMBL7809239 | 0.75 | ALOX5 (0.49) | ALOX5ADORA1ADORA2B | |
| SCHEMBL7816278 | 0.74 | ALOX5 (0.50) | ALOX5MAOAMAOB | |
| SCHEMBL9009118 | 0.72 | ALOX5 (0.42) | ALOX5ADORA1HTR7ADORA2A | |
| SCHEMBL7812804 | 0.70 | ALOX5 (0.46) | ALOX5ADORA1LRRK2ADORA2A | |
| SCHEMBL7809116 | 0.68 | ALOX5 (0.37) | ALOX5LRRK2 | |
| SCHEMBL7812678 | 0.67 | ALOX5 (0.47) | ALOX5 | |
| SCHEMBL9009080 | 0.66 | ALOX5 (0.66) | ALOX5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0788497-B1 | BISARYLCARBINOL DERIVATIVES AS INHIBITORS OF LEUKOTRIENE BIOSYNTHESIS | MERCK FROSST CANADA INC (CA) | 2001-05-23 | — | — | EP | disclosed |
| US-5552437-A | ANTIASTHMATIC, ANTIALLERGIC, ANTIINFLAMMATORY, AND CYTOPROTECTIVE AGENTS | MERCK FROSST CANADA, INC. (CA) | 1996-09-03 | — | — | US | disclosed |
| WO-1996013500-A1 | BISARYLCARBINOL DERIVATIVES AS INHIBITORS OF LEUKOTRIENE BIOSYNTHESIS | MERCK FROSST CANADA INC. (CA) | 1996-05-09 | — | — | WO | disclosed |