Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 10/20 | 0.46 |
| ▸ | PLAU | P00749 | 2/20 | 0.42 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.42 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.42 |
| ▸ | SLC22A12 | Q96S37 | 2/20 | 0.40 |
| ▸ | XDH | P47989 | 1/20 | 0.40 |
| ▸ | LCK | P06239 | 1/20 | 0.40 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.39 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.38 |
| ▸ | F2 | P00734 | 1/20 | 0.37 |
| ▸ | PLG | P00747 | 1/20 | 0.37 |
| ▸ | PLAT | P00750 | 1/20 | 0.37 |
| ▸ | KLK1 | P06870 | 1/20 | 0.37 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.37 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9301220 | 0.79 | PTGER2 (0.43) | ALOX5PLAUADORA2AADORA1XDH | |
| SCHEMBL7816757 | 0.78 | ALOX5 (0.49) | ALOX5SLC22A12XDH | |
| SCHEMBL7812869 | 0.75 | ALOX5 (0.45) | ALOX5ADORA2AADORA1SLC22A12XDH | |
| SCHEMBL7813258 | 0.75 | ALOX5 (0.45) | ALOX5ADORA2AADORA1SLC22A12XDH | |
| SCHEMBL7809239 | 0.75 | ALOX5 (0.49) | ALOX5PLAUADORA1SLC22A12XDH | |
| SCHEMBL5566033 | 0.72 | PLAU (0.64) | PLAUXDHLCKF2PLG | |
| SCHEMBL4331915 | 0.71 | ASH1L (0.60) | NR4A2PTGER2 | |
| SCHEMBL19899928 | 0.71 | KDM4E (0.49) | ADORA2AADORA1XDHNR4A2PTGER2 | |
| SCHEMBL7812678 | 0.71 | ALOX5 (0.47) | ALOX5SLC22A12XDH | |
| SCHEMBL20906151 | 0.71 | SLC22A12 (0.73) | PLAUSLC22A12XDH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0788497-B1 | BISARYLCARBINOL DERIVATIVES AS INHIBITORS OF LEUKOTRIENE BIOSYNTHESIS | MERCK FROSST CANADA INC (CA) | 2001-05-23 | — | — | EP | disclosed |
| US-5552437-A | ANTIASTHMATIC, ANTIALLERGIC, ANTIINFLAMMATORY, AND CYTOPROTECTIVE AGENTS | MERCK FROSST CANADA, INC. (CA) | 1996-09-03 | — | — | US | disclosed |
| WO-1996013500-A1 | BISARYLCARBINOL DERIVATIVES AS INHIBITORS OF LEUKOTRIENE BIOSYNTHESIS | MERCK FROSST CANADA INC. (CA) | 1996-05-09 | — | — | WO | disclosed |