Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 13/20 | 0.49 |
| ▸ | PLAU | P00749 | 1/20 | 0.36 |
| ▸ | XDH | P47989 | 2/20 | 0.36 |
| ▸ | SLC22A12 | Q96S37 | 2/20 | 0.36 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.35 |
| ▸ | FYN | P06241 | 1/20 | 0.34 |
| ▸ | KDM1A | O60341 | 1/20 | 0.33 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.33 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7816757 | 0.83 | ALOX5 (0.49) | ALOX5XDHSLC22A12 | |
| SCHEMBL7813258 | 0.80 | ALOX5 (0.45) | ALOX5XDHSLC22A12KDM1AADORA1 | |
| SCHEMBL7812869 | 0.80 | ALOX5 (0.45) | ALOX5XDHSLC22A12ADORA1 | |
| SCHEMBL9140071 | 0.78 | ALOX5 (0.49) | ALOX5 | |
| SCHEMBL7812804 | 0.75 | ALOX5 (0.46) | ALOX5PLAUXDHSLC22A12ADORA1 | |
| SCHEMBL7803620 | 0.75 | ALOX5 (0.44) | ALOX5ADORA2BADORA1 | |
| SCHEMBL7812678 | 0.71 | ALOX5 (0.47) | ALOX5XDHSLC22A12 | |
| SCHEMBL9009008 | 0.70 | ALOX5 (0.67) | ALOX5 | |
| SCHEMBL7809116 | 0.69 | ALOX5 (0.37) | ALOX5PLAUXDHSLC22A12 | |
| SCHEMBL9009118 | 0.68 | ALOX5 (0.42) | ALOX5XDHSLC22A12ADORA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0788497-B1 | BISARYLCARBINOL DERIVATIVES AS INHIBITORS OF LEUKOTRIENE BIOSYNTHESIS | MERCK FROSST CANADA INC (CA) | 2001-05-23 | — | — | EP | disclosed |
| US-5552437-A | ANTIASTHMATIC, ANTIALLERGIC, ANTIINFLAMMATORY, AND CYTOPROTECTIVE AGENTS | MERCK FROSST CANADA, INC. (CA) | 1996-09-03 | — | — | US | disclosed |
| WO-1996013500-A1 | BISARYLCARBINOL DERIVATIVES AS INHIBITORS OF LEUKOTRIENE BIOSYNTHESIS | MERCK FROSST CANADA INC. (CA) | 1996-05-09 | — | — | WO | disclosed |