Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 13/20 | 0.48 |
| ▸ | DRD4 | P21917 | 12/20 | 0.48 |
| ▸ | DRD3 | P35462 | 12/20 | 0.48 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.44 |
| ▸ | HTR1D | P28221 | 2/20 | 0.42 |
| ▸ | HTR1B | P28222 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | ACHE | P22303 | 2/20 | 0.40 |
| ▸ | HTR6 | P50406 | 1/20 | 0.40 |
| ▸ | BCHE | P06276 | 1/20 | 0.40 |
| ▸ | BACE1 | P56817 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8033624 | 0.99 | DRD2 (0.47) | DRD2DRD4DRD3SLC6A4HTR1D | |
| SCHEMBL7804925 | 0.91 | DRD2 (0.48) | DRD2DRD4DRD3SLC6A4HTR1D | |
| Hydrochloric Acid SCHEMBL8031557 | 0.90 | DRD2 (0.47) | DRD2DRD4DRD3SLC6A4HTR1D | |
| SCHEMBL7804305 | 0.87 | HTR1D (0.50) | DRD2SLC6A4HTR1DHTR1B | |
| Hydrochloric Acid SCHEMBL8021872 | 0.86 | HTR1D (0.49) | DRD2SLC6A4HTR1DHTR1B | |
| SCHEMBL7804169 | 0.85 | HTR1D (0.46) | DRD2DRD4SLC6A4HTR1DHTR1B | |
| SCHEMBL7808854 | 0.84 | DRD2 (0.48) | DRD2DRD4DRD3SLC6A4ALDH1A1 | |
| Hydrochloric Acid SCHEMBL8021805 | 0.84 | HTR1D (0.45) | DRD2DRD4SLC6A4HTR1DHTR1B | |
| Hydrochloric Acid SCHEMBL8031499 | 0.83 | DRD2 (0.47) | DRD2DRD4DRD3SLC6A4ALDH1A1 | |
| SCHEMBL7798179 | 0.83 | HTR1D (0.46) | DRD2SLC6A4HTR1DHTR1BALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0902027-B1 | Indole and indazole derivatives, process for their preparation and the pharmaceutical compositions containing them | ADIR (FR) | 2001-07-25 | — | — | EP | disclosed |
| US-6046205-A | FOR TREATMENT OF VENOUS INSUFFICIENCY AND OF ASSOCIATED DISORDERS, AND ALSO IN THE TREATMENT OF MIGRAINE | ADIR ET COMPAGNIE (FR) | 2000-04-04 | — | — | US | disclosed |
| US-6020336-A | Indole and indazole compounds | LES LABORATOIRES SERVIER (FR) | 2000-02-01 | — | — | US | disclosed |
| EP-0902027-A1 | Indole and indazole derivatives, process for their preparation and the pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1999-03-17 | — | — | EP | disclosed |