Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1D | P28221 | 14/20 | 0.50 |
| ▸ | HTR1B | P28222 | 14/20 | 0.50 |
| ▸ | DRD2 | P14416 | 1/20 | 0.46 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.46 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8021872 | 0.99 | HTR1D (0.49) | HTR1DHTR1BDRD2SLC6A4SIGMAR1 | |
| SCHEMBL7804156 | 0.87 | DRD2 (0.48) | HTR1DHTR1BDRD2SLC6A4 | |
| Hydrochloric Acid SCHEMBL8033624 | 0.86 | DRD2 (0.47) | HTR1DHTR1BDRD2SLC6A4 | |
| Hydrochloric Acid SCHEMBL27605387 | 0.81 | POLB (0.47) | — | |
| SCHEMBL7804925 | 0.79 | DRD2 (0.48) | HTR1DHTR1BDRD2SLC6A4 | |
| SCHEMBL7802607 | 0.79 | HTR1D (0.47) | HTR1DHTR1BDRD2SLC6A4 | |
| SCHEMBL7804093 | 0.78 | HTR1D (0.54) | HTR1DHTR1BDRD2SIGMAR1 | |
| Hydrochloric Acid SCHEMBL8031557 | 0.78 | DRD2 (0.47) | HTR1DHTR1BDRD2SLC6A4 | |
| Hydrochloric Acid SCHEMBL8033531 | 0.78 | HTR1A (0.46) | HTR1DHTR1BDRD2SLC6A4 | |
| SCHEMBL7804169 | 0.78 | HTR1D (0.46) | HTR1DHTR1BDRD2SLC6A4SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6046205-A | FOR TREATMENT OF VENOUS INSUFFICIENCY AND OF ASSOCIATED DISORDERS, AND ALSO IN THE TREATMENT OF MIGRAINE | ADIR ET COMPAGNIE (FR) | 2000-04-04 | — | — | US | claimed |
| EP-0902027-B1 | Indole and indazole derivatives, process for their preparation and the pharmaceutical compositions containing them | ADIR (FR) | 2001-07-25 | — | — | EP | disclosed |
| EP-0902027-A1 | Indole and indazole derivatives, process for their preparation and the pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1999-03-17 | — | — | EP | disclosed |