Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 7/20 | 0.57 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.43 |
| ▸ | HTR1A | P08908 | 1/20 | 0.43 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.43 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.43 |
| ▸ | DRD1 | P21728 | 1/20 | 0.43 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.43 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.43 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.43 |
| ▸ | DRD3 | P35462 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8373553 | 0.82 | SIGMAR1 (0.57) | SIGMAR1CYP2D6MAPTKDM4EMEN1 | |
| SCHEMBL25501652 | 0.80 | SIGMAR1 (0.42) | SIGMAR1LMNATP53CYP2D6TSHR | |
| SCHEMBL25501658 | 0.80 | SIGMAR1 (0.42) | SIGMAR1LMNATP53CYP2D6TSHR | |
| SCHEMBL25501641 | 0.80 | SIGMAR1 (0.42) | SIGMAR1LMNATP53CYP2D6TSHR | |
| SCHEMBL23848244 | 0.78 | CHRNA7 (0.41) | SIGMAR1CHRNA7OPRM1 | |
| SCHEMBL25171652 | 0.78 | CA1 (0.42) | CHRNA7TSHRALDH1A1 | |
| SCHEMBL23832762 | 0.78 | CA1 (0.42) | CHRNA7TSHRALDH1A1 | |
| SCHEMBL25502447 | 0.74 | ALDH1A1 (0.41) | CHRNA7CYP2D6TSHRALDH1A1CYP3A4 | |
| SCHEMBL9307181 | 0.73 | SIGMAR1 (1.00) | SIGMAR1 | |
| SCHEMBL861127 | 0.73 | SIGMAR1 (0.63) | SIGMAR1MAPTKDM4EMEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230146127-A1 | 3-DIARYLMETHYLENES AND USES THEREOF | ATUX ISKAY LLC | 2023-05-11 | — | — | US | disclosed |
| EP-0733043-B1 | TRICYCLIC DERIVATIVES AND THEIR USE IN PHARMACEUTICALS | SCHERING CORP (US) | 2001-06-20 | — | — | EP | disclosed |
| US-5464840-A | Pharmaceuticals to inhibit tumor necrosis factor-alpha and to treat septic shock, inflammation and allergic disease | SCHERING CORPORATION (US) | 1995-11-07 | — | — | US | disclosed |
| WO-1995015949-A1 | TRICYCLIC DERIVATIVES AND THEIR USE IN PHARMACEUTICALS | SCHERING CORPORATION (US) | 1995-06-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230146127-A1 | 3-DIARYLMETHYLENES AND USES THEREOF | MYC, MYCBP, FOXO1 | SIGMAR1 3676/4885CHRNA7 3918/4885LMNA 1859/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.