Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.54 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.54 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.54 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | PLA2G4B | P0C869 | 1/20 | 0.50 |
| ▸ | LTA4H | P09960 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.49 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1496573 | 1.00 | LMNA (0.56) | LMNACYP2D6ADRB2ADRB1ADRB3 | |
| SCHEMBL1496614 | 0.94 | LTA4H (0.62) | LMNACYP2D6ADRB2ADRB1ADRB3 | |
| SCHEMBL382120 | 0.93 | PLA2G4B (0.55) | LMNACYP2D6ADRB2ADRB1ADRB3 | |
| SCHEMBL9797717 | 0.93 | PLA2G4B (0.55) | LMNACYP2D6ADRB2ADRB1ADRB3 | |
| SCHEMBL9797915 | 0.93 | PLA2G4B (0.55) | LMNACYP2D6ADRB2ADRB1ADRB3 | |
| SCHEMBL6231558 | 0.93 | PLA2G4B (0.55) | LMNACYP2D6ADRB2ADRB1ADRB3 | |
| SCHEMBL21990 | 0.93 | PLA2G4B (0.55) | LMNACYP2D6ADRB2ADRB1ADRB3 | |
| SCHEMBL6032899 | 0.89 | LMNA (0.60) | LMNACYP2D6ADRB2ADRB1ADRB3 | |
| SCHEMBL11077119 | 0.86 | CDK4 (0.54) | CYP2D6ADRB2ADRB1ADRB3PLA2G4B | |
| Phosphoric Acid SCHEMBL1347351 | 0.86 | S1PR1 (0.60) | LMNACYP2D6ADRB2ADRB1ADRB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1104395-A1 | STEREOSELECTIVE RING OPENING REACTIONS | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2001-06-06 | — | — | EP | disclosed |
| WO-2000009463-A1 | STEREOSELECTIVE RING OPENING REACTIONS | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2000-02-24 | — | — | WO | disclosed |