Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 1/20 | 0.37 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.34 |
| ▸ | HTR2C | P28335 | 2/20 | 0.33 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.31 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.31 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | PNMT | P11086 | 1/20 | 0.30 |
| ▸ | CD44 | P16070 | 1/20 | 0.30 |
| ▸ | MAOB | P27338 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7809704 | 0.74 | MAPK1 (0.38) | SIGMAR1ADRA2AADRA2BADRA2CMAOB | |
| Iodide SCHEMBL7813387 | 0.73 | SIGMAR1 (0.31) | SIGMAR1 | |
| SCHEMBL7813352 | 0.70 | SIGMAR1 (0.44) | HTR2ASIGMAR1HTR2CMEN1 | |
| SCHEMBL7817126 | 0.69 | NOTUM (0.40) | SIGMAR1MEN1 | |
| SCHEMBL10952661 | 0.66 | LMNA (0.49) | HTR2ASIGMAR1 | |
| SCHEMBL8817015 | 0.66 | MEN1 (0.40) | HTR2ASIGMAR1HTR2CADRA2AADRA2B | |
| SCHEMBL8506381 | 0.64 | SIGMAR1 (0.38) | HTR2ASIGMAR1HTR2CADRA2AMEN1 | |
| SCHEMBL175960 | 0.64 | MEN1 (0.39) | HTR2ASIGMAR1MEN1 | |
| SCHEMBL29501701 | 0.63 | SIGMAR1 (0.43) | HTR2ASIGMAR1MAOB | |
| SCHEMBL8507250 | 0.63 | CCR1 (0.42) | HTR2ASIGMAR1MEN1MAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0733043-B1 | TRICYCLIC DERIVATIVES AND THEIR USE IN PHARMACEUTICALS | SCHERING CORP (US) | 2001-06-20 | — | — | EP | disclosed |
| EP-0733043-A1 | TRICYCLIC DERIVATIVES AND THEIR USE IN PHARMACEUTICALS | SCHERING CORPORATION (US) | 1996-09-25 | — | — | EP | disclosed |
| US-5464840-A | Pharmaceuticals to inhibit tumor necrosis factor-alpha and to treat septic shock, inflammation and allergic disease | SCHERING CORPORATION (US) | 1995-11-07 | — | — | US | disclosed |
| WO-1995015949-A1 | TRICYCLIC DERIVATIVES AND THEIR USE IN PHARMACEUTICALS | SCHERING CORPORATION (US) | 1995-06-15 | — | — | WO | disclosed |