SCHEMBL8507250

SCHEMBL8507250

C=CCC1(C#N)c2ccccc2CCc2ccccc21

nearest known ligand 0.42

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
CCR1 P32246 6/20 0.42
SIGMAR1 Q99720 5/20 0.40
HTR2A P28223 1/20 0.37
MEN1 O00255 1/20 0.36
KDM1A O60341 1/20 0.34
MAOB P27338 1/20 0.34
PGR P06401 1/20 0.33
LMNA P02545 1/20 0.33
PRCP P42785 1/20 0.32
ALDH1A1 P00352 1/20 0.32
TP53 P04637 1/20 0.32
CYP1A2 P05177 1/20 0.32
CYP3A4 P08684 1/20 0.32
CYP2D6 P10635 1/20 0.32
CYP2C9 P11712 1/20 0.32
TSHR P16473 1/20 0.32
CYP2C19 P33261 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9198384 0.84 CCR1 (0.43) CCR1SIGMAR1HTR2AMEN1LMNA
SCHEMBL9426817 0.75 CCR1 (0.45) CCR1HTR2AKDM1AMAOBLMNA
SCHEMBL8255534 0.75 CCR1 (0.45) CCR1HTR2AKDM1AMAOBLMNA
SCHEMBL8251316 0.75 CCR1 (0.45) CCR1HTR2AKDM1AMAOBLMNA
SCHEMBL29501701 0.74 SIGMAR1 (0.43) SIGMAR1HTR2AKDM1AMAOBALDH1A1
SCHEMBL10952661 0.74 LMNA (0.49) SIGMAR1HTR2ALMNACYP2D6TSHR
SCHEMBL13548795 0.73 CCR1 (0.44) CCR1HTR2AKDM1AMAOBLMNA
SCHEMBL13552352 0.72 CCR1 (0.44) CCR1HTR2AKDM1AMAOBLMNA
SCHEMBL9845104 0.72 CCR1 (0.52) CCR1SIGMAR1HTR2ALMNAALDH1A1
SCHEMBL8506381 0.71 SIGMAR1 (0.38) SIGMAR1HTR2AMEN1KDM1AMAOB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0733035-B1 TRICYCLIC DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM SCHERING CORP (US) 1999-03-31 EP disclosed
EP-0733035-A1 TRICYCLIC DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM SCHERING CORPORATION (US) 1996-09-25 EP disclosed
US-5538986-A INHIBITORS OF TUMOR NECROSIS FACTOR-ALPHA, DIBENZOCYCLOHEPTANE AND DIBENZOXEPINE DERIVATIVES SCHERING CORPORATION (US) 1996-07-23 US disclosed
EP-0456183-B1 Spiro dibenzosuberane derivatives SHIONOGI & CO (JP) 1995-10-04 EP disclosed
WO-1995015939-A1 TRICYCLIC DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM SCHERING CORPORATION (US) 1995-06-15 WO disclosed