Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERBB2 | P04626 | 1/20 | 0.55 |
| ▸ | MINK1 | Q8N4C8 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.51 |
| ▸ | NPC1 | O15118 | 3/20 | 0.51 |
| ▸ | RAB9A | P51151 | 3/20 | 0.51 |
| ▸ | LMNA | P02545 | 3/20 | 0.51 |
| ▸ | TP53 | P04637 | 3/20 | 0.51 |
| ▸ | MAPT | P10636 | 3/20 | 0.51 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.51 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.51 |
| ▸ | RELA | Q04206 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL780446 | 1.00 | ERBB2 (0.55) | ERBB2MINK1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL5758919 | 0.97 | ERBB2 (0.58) | ERBB2MINK1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL5758915 | 0.97 | ERBB2 (0.58) | ERBB2MINK1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL5762709 | 0.96 | ERBB2 (0.57) | ERBB2MINK1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL5758033 | 0.96 | ERBB2 (0.57) | ERBB2MINK1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL5762705 | 0.96 | ERBB2 (0.57) | ERBB2MINK1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL5758026 | 0.96 | ERBB2 (0.57) | ERBB2MINK1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL5760576 | 0.94 | ERBB2 (0.50) | ERBB2MINK1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL5760578 | 0.94 | ERBB2 (0.50) | ERBB2MINK1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL5760352 | 0.90 | NPC1 (0.46) | ERBB2MINK1SMN1; SMN2NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 46 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-11060571-A | — | — | None | — | — | JP | disclosed |
| US-9346822-B2 | Thienopyrimidine compounds and use thereof | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2016-05-24 | — | — | US | disclosed |
| EP-1917978-B1 | Premature ovulation preventive agent | TAKEDA PHARMACEUTICAL (JP) | 2014-08-20 | — | — | EP | disclosed |
| US-20140221381-A1 | THIENOPYRIMIDINE COMPOUNDS AND USE THEREOF | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2014-08-07 | — | — | US | disclosed |
| US-8735401-B2 | Thienopyrimidine compounds and use thereof | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2014-05-27 | — | — | US | disclosed |
| EP-1591446-B1 | Thienopyrimidine compounds and use thereof | TAKEDA PHARMACEUTICAL (JP) | 2013-03-06 | — | — | EP | disclosed |
| US-20120071486-A1 | THIENOPYRIMIDINE COMPOUNDS AND USE THEREOF | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-22 | — | — | US | disclosed |
| US-8058280-B2 | Substituted thieno[2,3-d]pyrimidin-2,4-dione compounds and uses thereof | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2011-11-15 | — | — | US | disclosed |
| US-20110172249-A1 | METHOD FOR IMPROVING ABSORBABILITY OF PREPARATION, AND PREPARATION HAVING IMPROVED ABSORBABILITY | TAKEDA PHARMACEUTICAL COMPANY LIMTED (JP) | 2011-07-14 | — | — | US | disclosed |
| EP-2329823-A1 | METHOD FOR IMPROVING ABSORBABILITY OF PREPARATION, AND PREPARATION HAVING IMPROVED ABSORBABILITY | Takeda Pharmaceutical Company Limited (JP) | 2011-06-08 | — | — | EP | disclosed |
| EP-1319409-A1 | SOLID PREPARATIONS | Takeda Chemical Industries, Ltd. (JP) | 2003-06-18 | — | — | EP | disclosed |
| EP-1291023-A1 | SUSTAINED RELEASE COMPOSITIONS | Takeda Chemical Industries, Ltd. (JP) | 2003-03-12 | — | — | EP | disclosed |
| EP-1270571-A1 | Heterocyclic compounds, their production and use | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2003-01-02 | — | — | EP | disclosed |
| US-6340686-B1 | GONADOTROPIN-RELEASING HORMONE ANTAGONISTS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2002-01-22 | — | — | US | disclosed |
| EP-1163244-A1 | THIENOPYRIMIDINE COMPOUNDS, THEIR PRODUCTION AND USE | Takeda Chemical Industries, Ltd. (JP) | 2001-12-19 | — | — | EP | disclosed |
| US-6297379-B1 | GONADOTROPIN RELEASING HORMONE (GNRH, SOMETIMES CALLED LH-RH (LUTEINIZING HORMONE RELEASING HORMONE)) ANTAGONIZING ACTIVITY, TREATING SEX HORMONE-DEPENDENT DISEASES. | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2001-10-02 | — | — | US | disclosed |
| EP-1136079-A1 | AGENTS FOR RETARDING CHANGE OF HORMONE-DEPENDENT CANCER INTO HORMONE-INDEPENDENT CANCER | Takeda Chemical Industries, Ltd. (JP) | 2001-09-26 | — | — | EP | disclosed |
| US-6211215-B1 | AROMATIC HETEROCYCLIC COMPOUND WITH AZOLE COMPOUND | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2001-04-03 | — | — | US | disclosed |
| WO-2000056739-A1 | THIENOPYRIMIDINE COMPOUNDS, THEIR PRODUCTION AND USE | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2000-09-28 | — | — | WO | disclosed |
| JP-H1160571-A | HETEROCYCLIC COMPOUND, ITS PRODUCTION AND USE | TAKEDA CHEM IND LTD | 1999-03-02 | — | — | JP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120071486-A1 | THIENOPYRIMIDINE COMPOUNDS AND USE THEREOF | GNRHR, KISS1R, NR5A1 | ERBB2 1152/4885MINK1 2908/4885SMN1; SMN2 4442/4885 |
| US-20110172249-A1 | METHOD FOR IMPROVING ABSORBABILITY OF PREPARATION, AND PREPARATION HAVING IMPROVED ABSORBABILITY | SI, SLC10A2, FABP2 | ERBB2 4841/4885MINK1 4022/4885SMN1; SMN2 3330/4885 |
| US-20140221381-A1 | THIENOPYRIMIDINE COMPOUNDS AND USE THEREOF | GNRHR, KISS1R, NR5A1 | ERBB2 1152/4885MINK1 2908/4885SMN1; SMN2 4442/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.