SCHEMBL7804606

SCHEMBL7804606

CC(C)(Oc1cccc(N2CCN(C(=O)c3ccco3)CC2)c1)C(=O)O

nearest known ligand 0.63

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 6/20 0.63
USP2 O75604 5/20 0.63
TSHR P16473 1/20 0.63
HSD17B10 Q99714 2/20 0.56
ALOX15 P16050 1/20 0.56
NPC1 O15118 2/20 0.53
KMT2A Q03164 2/20 0.53
SMN1; SMN2 Q16637 6/20 0.53
ALDH1A1 P00352 6/20 0.53
CYP2C19 P33261 3/20 0.53
LMNA P02545 2/20 0.53
RAB9A P51151 1/20 0.53
GAA P10253 1/20 0.53
CYP2C9 P11712 1/20 0.53
ALOX12 P18054 1/20 0.53
GFER P55789 1/20 0.53
CYP1A2 P05177 2/20 0.53
CYP2D6 P10635 1/20 0.51
CXCR4 P61073 1/20 0.51
KDM4E B2RXH2 1/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7817791 0.89 MAPT (0.61) MAPTUSP2TSHRHSD17B10ALOX15
SCHEMBL7813655 0.83 MAPT (0.59) MAPTUSP2TSHRKMT2AALDH1A1
SCHEMBL7813798 0.82 BCL9 (0.58) NPC1KMT2AALDH1A1RAB9A
SCHEMBL7813466 0.82 CYP1A2 (0.48) USP2TSHRHSD17B10KMT2ASMN1; SMN2
SCHEMBL7811727 0.80 PPARG (0.52) MAPTUSP2TSHRSMN1; SMN2ALDH1A1
SCHEMBL7811474 0.80 MAPT (0.65) MAPTUSP2TSHRHSD17B10ALOX15
SCHEMBL7811529 0.80 ALDH1A1 (0.56) MAPTUSP2TSHRHSD17B10SMN1; SMN2
SCHEMBL7813606 0.79 MAPT (0.58) MAPTTSHRALOX15SMN1; SMN2ALDH1A1
SCHEMBL7814070 0.79 SMN1; SMN2 (0.54) MAPTUSP2TSHRKMT2ASMN1; SMN2
SCHEMBL7810027 0.79 MAPT (0.50) MAPTUSP2TSHRKMT2ASMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0607536-B1 Arylamide derivatives SS PHARMACEUTICAL CO (JP) 2001-01-24 EP disclosed
US-5532371-A SIDE EFFECT REDUCTION SS PHARMACEUTICAL CO., LTD. (JP) 1996-07-02 US disclosed
US-5411972-A Arylamide derivatives for treating hyperlipemia SS PHARMACEUTICAL CO., LTD. (JP) 1995-05-02 US disclosed
EP-0607536-A1 Arylamide derivatives SS PHARMACEUTICAL CO., LTD. (JP) 1994-07-27 EP disclosed