SCHEMBL7804885

SCHEMBL7804885

Oc1ccccc1-c1ccn(-c2ccccc2)c1

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
COMT P21964 3/20 0.53
HPGD P15428 2/20 0.52
ALDH1A1 P00352 1/20 0.52
BCL2L1 Q07817 1/20 0.52
HSD17B10 Q99714 1/20 0.52
KDM4A O75164 1/20 0.39
CYP3A4 P08684 1/20 0.37
USP2 O75604 1/20 0.37
ESR2 Q92731 1/20 0.37
SMN1; SMN2 Q16637 2/20 0.37
MEN1 O00255 2/20 0.37
KMT2A Q03164 2/20 0.37
LMNA P02545 2/20 0.37
CASP3 P42574 1/20 0.37
RAB9A P51151 1/20 0.37
SENP8 Q96LD8 1/20 0.37
SENP7 Q9BQF6 1/20 0.37
SENP6 Q9GZR1 1/20 0.37
BRD4 O60885 1/20 0.37
NR1I2 O75469 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14007395 0.76 COMT (0.48) COMTHPGDALDH1A1CYP3A4MEN1
SCHEMBL17267004 0.76 COMT (0.48) COMTHPGDALDH1A1CYP3A4MEN1
SCHEMBL1660428 0.75 ALOX5 (0.55) COMTHPGDALDH1A1HSD17B10USP2
SCHEMBL7807352 0.74 TUBB4A (0.46) HPGDALDH1A1HSD17B10SMN1; SMN2MEN1
2-Phenylphenol SCHEMBL28399353 0.73 ALDH1A1 (0.94) HPGDALDH1A1BCL2L1HSD17B10CYP3A4
2-Phenylphenol SCHEMBL18889073 0.73 ALDH1A1 (0.94) HPGDALDH1A1BCL2L1HSD17B10CYP3A4
SCHEMBL29112127 0.71 COMT (0.59) COMTHPGDCYP3A4ESR2TDP1
SCHEMBL10059932 0.70 ALDH1A1 (0.50) COMTHPGDALDH1A1BCL2L1HSD17B10
2-Phenylphenol SCHEMBL14249267 0.70 ALDH1A1 (1.00) HPGDALDH1A1BCL2L1HSD17B10CYP3A4
2-Phenylphenol SCHEMBL29360750 0.70 ALDH1A1 (1.00) HPGDALDH1A1BCL2L1HSD17B10CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6255327-B1 ANTIHYPOXC, ANTIISCHEMIC AGENTS BOEHRINGER INGELHEIM PHARMA KG (DE) 2001-07-03 US disclosed
EP-1071670-A1 NOVEL DIPHENYL-SUBSTITUTED 5-RING-HETEROCYCLES, METHOD FOR PRODUCING THEM AND THEIR USE AS MEDICAMENTS BOEHRINGER INGELHEIM KG (DE) 2001-01-31 EP disclosed
WO-1999054314-A1 NOVEL DIPHENYL-SUBSTITUTED 5-RING-HETEROCYCLES, METHOD FOR PRODUCING THEM AND THEIR USE AS MEDICAMENTS BOEHRINGER INGELHEIM PHARMA KG (DE) 1999-10-28 WO disclosed