Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 4/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | ESR1 | P03372 | 1/20 | 0.44 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.44 |
| ▸ | GALR3 | O60755 | 1/20 | 0.44 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.43 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.43 |
| ▸ | HTR1A | P08908 | 1/20 | 0.43 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.43 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.43 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.43 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.43 |
| ▸ | DRD1 | P21728 | 1/20 | 0.43 |
| ▸ | HTR7 | P34969 | 1/20 | 0.43 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.43 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.43 |
| ▸ | DRD3 | P35462 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2847713 | 0.88 | LMNA (0.46) | HIF1ALMNAESR1ESR2GALR3 | |
| SCHEMBL17147285 | 0.85 | PSEN1 (0.50) | SLC6A3KDM4EGAAKMT2AMEN1 | |
| SCHEMBL30912668 | 0.83 | KYNU (0.49) | HIF1ALMNAGALR3ADRB2ADRB1 | |
| SCHEMBL1049247 | 0.83 | KYNU (0.49) | HIF1ALMNAGALR3ADRB2ADRB1 | |
| SCHEMBL2288515 | 0.82 | KMT2A (0.56) | ESR1ESR2GAAKMT2AMEN1 | |
| SCHEMBL2848810 | 0.82 | ESR1 (0.44) | HIF1ALMNAESR1ESR2GALR3 | |
| SCHEMBL29378831 | 0.81 | KYNU (0.44) | HIF1ALMNAGALR3ADRB2ADRB1 | |
| Water SCHEMBL27364395 | 0.81 | KMT2A (0.55) | ESR1ESR2GAAKMT2AMEN1 | |
| SCHEMBL2848191 | 0.81 | ESR1 (0.43) | HIF1ALMNAESR1ESR2GALR3 | |
| SCHEMBL15701020 | 0.80 | TAS1R3 (0.52) | LMNAKMT2AMEN1TAS1R3TAS1R1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010138901-A1 | CARBOXYLIC ACID-CONTAINING COMPOUNDS, DERIVATIVES THEREOF, AND RELATED METHODS OF USE | BIOGEN IDEC MA INC (US) | 2010-12-02 | — | — | WO | disclosed |