Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.52 |
| ▸ | RAB9A | P51151 | 4/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.49 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.48 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.47 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.46 |
| ▸ | MAOB | P27338 | 4/20 | 0.45 |
| ▸ | AS3MT | Q9HBK9 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | MAOA | P21397 | 1/20 | 0.43 |
| ▸ | ACSS2 | Q9NR19 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7805459 | 0.89 | NPC1 (0.49) | NPC1RAB9AMEN1KMT2ACYP3A4 | |
| SCHEMBL7805200 | 0.77 | RHEB (0.45) | NPC1RAB9ASRD5A2PKMSMN1; SMN2 | |
| SCHEMBL5448369 | 0.70 | MEN1 (0.53) | NPC1RAB9AMEN1KMT2ASRD5A2 | |
| SCHEMBL1400791 | 0.70 | NPC1 (0.63) | NPC1RAB9AMEN1KMT2ASRD5A2 | |
| SCHEMBL11227007 | 0.69 | ALDH1A1 (0.55) | NPC1RAB9AMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL28021758 | 0.69 | HDAC6 (0.58) | NPC1RAB9AMEN1KMT2ACYP3A4 | |
| SCHEMBL7814303 | 0.69 | MAPT (0.48) | NPC1RAB9AMEN1KMT2ACYP3A4 | |
| SCHEMBL7818433 | 0.69 | FGFR1 (0.38) | MEN1KMT2AALOX5SMN1; SMN2 | |
| SCHEMBL27707473 | 0.69 | CYP3A4 (0.51) | NPC1RAB9ACYP3A4SRD5A2ALOX5 | |
| SCHEMBL11337508 | 0.69 | MAOB (0.50) | NPC1RAB9AMEN1KMT2ACYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0745600-B1 | Benzimidazole derivatives, their preparation and their therapeutic use | SANKYO CO (JP) | 2001-10-24 | — | — | EP | disclosed |
| US-5886014-A | TREATMENT AND/OR PROPHYLAXIS OF A VARIETY OF DISORDERS, INCLUDING HYPERLIPEMIA, HYPERGLYCEMIA, OBESITY, IMPAIRED GLUCOSE TOLERANCE (IGT), INSULIN RESISTANCE AND DIABETIC COMPLICATIONS | SANKYO COMPANY, LIMITED (JP) | 1999-03-23 | — | — | US | disclosed |
| EP-0745600-A1 | Benzimidazole derivatives, their preparation and their therapeutic use | SANKYO COMPANY LIMITED (JP) | 1996-12-04 | — | — | EP | disclosed |