Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | MAPK14 | Q16539 | 8/20 | 0.47 |
| ▸ | SMO | Q99835 | 1/20 | 0.46 |
| ▸ | PDE4A | P27815 | 3/20 | 0.45 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.45 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.45 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.45 |
| ▸ | PDE5A | O76074 | 1/20 | 0.44 |
| ▸ | PDE1A | P54750 | 1/20 | 0.44 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.44 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.44 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6477326 | 0.94 | MAPK14 (0.54) | MAPTMEN1ALDH1A1PKMKMT2A | |
| SCHEMBL7809442 | 0.89 | MAPK14 (0.52) | MEN1KMT2AMAPK14SMOTGFBR1 | |
| SCHEMBL7804552 | 0.89 | OPRK1 (0.54) | ALDH1A1MAPK14SMOSMN1; SMN2TGFBR1 | |
| SCHEMBL7807962 | 0.87 | MAPT (0.54) | MAPTMEN1ALDH1A1PKMKMT2A | |
| SCHEMBL7806472 | 0.85 | OPRK1 (0.51) | ALDH1A1MAPK14SMOTBK1SMN1; SMN2 | |
| SCHEMBL6972611 | 0.84 | MAPK14 (0.57) | MAPTMEN1ALDH1A1PKMKMT2A | |
| SCHEMBL2972096 | 0.84 | OPRK1 (0.58) | MAPK14SMO | |
| SCHEMBL6476511 | 0.84 | MAPK14 (0.62) | MAPK14SMO | |
| SCHEMBL7856980 | 0.83 | OPRK1 (0.54) | MAPK14SMO | |
| SCHEMBL6476766 | 0.83 | OPRK1 (0.59) | ALDH1A1MAPK14SMO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1077931-A1 | BENZAMIDE DERIVATIVES FOR THE TREATMENT OF DISEASES MEDIATED BY CYTOKINES | AstraZeneca AB (SE) | 2001-02-28 | — | — | EP | disclosed |
| WO-1999059959-A1 | BENZAMIDE DERIVATIVES FOR THE TREATMENT OF DISEASES MEDIATED BY CYTOKINES | ASTRAZENECA AB (SE) | 1999-11-25 | — | — | WO | disclosed |