Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 2/20 | 0.41 |
| ▸ | HTR1D | P28221 | 10/20 | 0.37 |
| ▸ | HTR1B | P28222 | 10/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | CASP1 | P29466 | 1/20 | 0.34 |
| ▸ | CASP4 | P49662 | 1/20 | 0.34 |
| ▸ | CASP5 | P51878 | 1/20 | 0.34 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.33 |
| ▸ | CDK4 | P11802 | 1/20 | 0.33 |
| ▸ | CCND1 | P24385 | 1/20 | 0.33 |
| ▸ | HTR1A | P08908 | 1/20 | 0.33 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.32 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8021907 | 0.99 | BRD4 (0.41) | BRD4HTR1DHTR1BPKMCASP1 | |
| SCHEMBL7798296 | 0.83 | HTR7 (0.40) | HTR1DHTR1BCASP1CASP4CASP5 | |
| Hydrochloric Acid SCHEMBL8162484 | 0.82 | HTR7 (0.40) | HTR1DHTR1BCASP1CASP4CASP5 | |
| SCHEMBL7804960 | 0.81 | HTR1D (0.44) | HTR1DHTR1BSIGMAR1 | |
| Hydrochloric Acid SCHEMBL8033560 | 0.81 | HTR1D (0.43) | HTR1DHTR1BSIGMAR1 | |
| SCHEMBL7805916 | 0.79 | BRD4 (0.43) | BRD4PKMSIGMAR1 | |
| SCHEMBL7798163 | 0.75 | KDM1A (0.37) | BRD4 | |
| Hydrochloric Acid SCHEMBL8033418 | 0.74 | KDM1A (0.37) | BRD4 | |
| SCHEMBL7798170 | 0.73 | DRD2 (0.39) | HTR1DHTR1BCASP1CASP4CASP5 | |
| Hydrochloric Acid SCHEMBL8030850 | 0.72 | DRD2 (0.38) | CASP1CASP4CASP5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0902027-B1 | Indole and indazole derivatives, process for their preparation and the pharmaceutical compositions containing them | ADIR (FR) | 2001-07-25 | — | — | EP | disclosed |
| EP-0902027-A1 | Indole and indazole derivatives, process for their preparation and the pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1999-03-17 | — | — | EP | disclosed |