Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 10/20 | 0.47 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.41 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7807198 | 1.00 | PTGS2 (0.47) | PTGS2AKR1C3PTGS1NPC1RAB9A | |
| SCHEMBL7802249 | 0.90 | PTGS2 (0.48) | PTGS2PTGS1 | |
| SCHEMBL7802251 | 0.90 | PTGS2 (0.48) | PTGS2PTGS1 | |
| SCHEMBL7887232 | 0.90 | PTGS2 (0.48) | PTGS2PTGS1 | |
| SCHEMBL7808787 | 0.89 | KMT2A (0.38) | PTGS2PTGS1NPC1RAB9A | |
| SCHEMBL7808789 | 0.89 | KMT2A (0.38) | PTGS2PTGS1NPC1RAB9A | |
| SCHEMBL7807292 | 0.88 | PTGS2 (0.48) | PTGS2AKR1C3PTGS1 | |
| SCHEMBL7806930 | 0.88 | PTGS2 (0.46) | PTGS2AKR1C3PTGS1 | |
| SCHEMBL6882900 | 0.88 | AKR1C3 (0.42) | PTGS2AKR1C3PTGS1 | |
| SCHEMBL215270 | 0.88 | CA1 (0.49) | PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0891345-B1 | NOVEL FURAN DIARYLMETHYLIDENE DERIVATIVES, METHOD FOR THEIR PREPARATION AND THERAPEUTICAL USES THEREOF | UNION PHARMA SCIENT APPL (FR) | 2001-08-16 | — | — | EP | disclosed |
| US-6180651-B1 | ANTIINFLAMMATORY AGENTS; ANALGESICS | BRISTOL-MYERS SQUIBB | 2001-01-30 | — | — | US | disclosed |
| WO-2000014082-A1 | DIARYLMETHYLIDENE FURAN DERIVATIVES AS DRUGS WITH ANTI-INFLAMMATORY, ANALGESIC AND CHEMOPREVENTIVE PROPERTIES | LABORATORIES UPSA (FR) | 2000-03-16 | — | — | WO | disclosed |