Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7821489 | 0.85 | HTR1A (0.46) | HTR1A | |
| SCHEMBL7815137 | 0.81 | HTR1A (0.61) | HTR1A | |
| SCHEMBL8691042 | 0.78 | HTR1A (0.65) | HTR1A | |
| SCHEMBL7817890 | 0.76 | HTR1A (0.74) | HTR1A | |
| SCHEMBL7808439 | 0.76 | ADRB1 (0.59) | — | |
| Hydrochloric Acid SCHEMBL4182188 | 0.74 | ADRB1 (0.57) | — | |
| SCHEMBL5916271 | 0.74 | HTR1A (0.42) | HTR1A | |
| SCHEMBL7807894 | 0.73 | DRD2 (0.43) | HTR1A | |
| SCHEMBL2303114 | 0.72 | HTR1A (0.60) | HTR1A | |
| SCHEMBL7815669 | 0.71 | HTR1A (0.68) | HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0633260-B1 | 2,3-Dihydro-1,4-benzodioxan-5-yl-piperazine derivatives having 5-HT1A-antagonistic activity | DUPHAR INT RES (NL) | 2001-11-07 | — | — | EP | disclosed |
| US-5462942-A | 2,3-dihydro-1,4-benzodioxin-5-yl-piperazine derivatives having 5-HT 1A-antagonistic activity | DUPHAR INTERNATIONAL RESEARCH B.V. (NL) | 1995-10-31 | — | — | US | disclosed |
| EP-0633260-A1 | 2,3-Dihydro-1,4-benzodioxin-5-yl-piperazine derivatives having 5-HT1A-antagonistic activity | DUPHAR INTERNATIONAL RESEARCH B.V (NL) | 1995-01-11 | — | — | EP | disclosed |