Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | TNF | P01375 | 1/20 | 0.37 |
| ▸ | TACR2 | P21452 | 5/20 | 0.35 |
| ▸ | CCR2 | P41597 | 2/20 | 0.35 |
| ▸ | OXER1 | Q8TDS5 | 2/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7802831 | 0.85 | NOTUM (0.38) | NOTUMTSHRRAB9AL3MBTL1TNF | |
| SCHEMBL8913116 | 0.73 | PRKCZ (0.49) | TSHR | |
| SCHEMBL7815384 | 0.72 | HTT (0.53) | RAB9AL3MBTL1 | |
| SCHEMBL7811545 | 0.70 | GRM7 (0.48) | — | |
| SCHEMBL23282456 | 0.69 | NOTUM (0.56) | NOTUMTSHRRAB9AL3MBTL1 | |
| SCHEMBL7803133 | 0.68 | ALDH1A1 (0.50) | TACR2SLC6A2SLC6A4 | |
| SCHEMBL7873870 | 0.68 | ALDH1A1 (0.42) | L3MBTL1SLC6A2SLC6A4 | |
| SCHEMBL7873751 | 0.67 | F10 (0.45) | TSHRSLC6A2SLC6A4 | |
| SCHEMBL10837613 | 0.67 | NOTUM (0.59) | NOTUMTSHRRAB9AL3MBTL1OXER1 | |
| SCHEMBL7815209 | 0.67 | TACR1 (0.50) | RAB9ATACR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0773929-B1 | PIPERIDINE DERIVATIVES AS NEUROKININ ANTAGONISTS | SCHERING CORP (US) | 2001-10-31 | — | — | EP | disclosed |
| US-5654316-A | Piperidine derivatives as neurokinin antagonists | SCHERING CORPORATION (US) | 1997-08-05 | — | — | US | disclosed |