Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM7 | Q14831 | 3/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | DRD2 | P14416 | 1/20 | 0.46 |
| ▸ | DRD4 | P21917 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | SPR | P35270 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7815510 | 0.88 | GRM7 (0.47) | GRM7MAPTNPSR1HPGDSMN1; SMN2 | |
| SCHEMBL7812039 | 0.84 | TACR2 (0.58) | — | |
| SCHEMBL7815384 | 0.78 | HTT (0.53) | NPSR1HPGDSMN1; SMN2ALDH1A1POLB | |
| SCHEMBL19910587 | 0.72 | NOTUM (0.63) | GRM7NPSR1SMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL3456180 | 0.72 | MEN1 (0.72) | SMN1; SMN2ALDH1A1MEN1KMT2ASPR | |
| SCHEMBL18823655 | 0.71 | GRM7 (0.62) | GRM7MAPTSMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL342522 | 0.71 | SMN1; SMN2 (0.68) | GRM7SMN1; SMN2DRD2DRD4ALDH1A1 | |
| SCHEMBL8913116 | 0.71 | PRKCZ (0.49) | SMN1; SMN2ALDH1A1MEN1HTTKMT2A | |
| SCHEMBL8024014 | 0.71 | GRM7 (0.54) | GRM7NPSR1SMN1; SMN2DRD2DRD4 | |
| SCHEMBL19910611 | 0.70 | GRM7 (0.60) | GRM7NPSR1SMN1; SMN2ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0773929-B1 | PIPERIDINE DERIVATIVES AS NEUROKININ ANTAGONISTS | SCHERING CORP (US) | 2001-10-31 | — | — | EP | disclosed |
| US-5654316-A | Piperidine derivatives as neurokinin antagonists | SCHERING CORPORATION (US) | 1997-08-05 | — | — | US | disclosed |
| EP-0773929-A1 | PIPERIDINE DERIVATIVES AS NEUROKININ ANTAGONISTS | SCHERING CORPORATION (US) | 1997-05-21 | — | — | EP | disclosed |
| WO-1996039386-A1 | PIPERIDINE DERIVATIVES AS NEUROKININ ANTAGONISTS | SCHERING CORPORATION (US) | 1996-12-12 | — | — | WO | disclosed |