Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 4/20 | 0.39 |
| ▸ | NR1H2 | P55055 | 8/20 | 0.38 |
| ▸ | NR1H3 | Q13133 | 7/20 | 0.38 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.37 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.37 |
| ▸ | SRC | P12931 | 4/20 | 0.35 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.35 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3952747 | 1.00 | BRD4 (0.39) | BRD4NR1H2NR1H3HSD11B1ABCB1 | |
| SCHEMBL4303297 | 0.86 | ALDH1A1 (0.38) | — | |
| SCHEMBL3947235 | 0.85 | CYP1A2 (0.43) | BRD4NR1H2NR1H3HSD11B1SRC | |
| SCHEMBL8572979 | 0.85 | CYP1A2 (0.43) | BRD4NR1H2NR1H3HSD11B1SRC | |
| SCHEMBL7811591 | 0.83 | NPSR1 (0.45) | — | |
| SCHEMBL3948504 | 0.83 | ABCB1 (0.38) | BRD4ABCB1SRC | |
| SCHEMBL21286395 | 0.83 | ABCB1 (0.38) | BRD4ABCB1SRC | |
| SCHEMBL29985450 | 0.83 | ABCB1 (0.38) | BRD4ABCB1SRC | |
| SCHEMBL19674208 | 0.83 | HSD17B10 (0.40) | BRD4NR1H2NR1H3HSD11B1SRC | |
| SCHEMBL20783314 | 0.82 | SRC (0.40) | BRD4HSD11B1SRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0528678-B1 | A pyrrolidylthiocarbapenem derivative with antibacterial activity | SHIONOGI & CO (JP) | 2001-05-23 | — | — | EP | disclosed |
| US-5703243-A | Intermediates for pyrrolidylthiocarbapenem derivative | SHIONOGI SEIYAKU KABUSHIKI KAISHA (JP) | 1997-12-30 | — | — | US | disclosed |
| US-5317016-A | Pyrrolidylthiocarbapenem derivative | SHIONOGI SEIYAKU KABUSHIKI KAISHA (JP) | 1994-05-31 | — | — | US | disclosed |
| EP-0528678-A1 | A pyrrolidylthiocarbapenem derivative | SHIONOGI SEIYAKU KABUSHIKI KAISHA trading under the name of SHIONOGI & CO. LTD. (JP) | 1993-02-24 | — | — | EP | disclosed |