Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR7 | P34969 | 2/20 | 0.52 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.42 |
| ▸ | ACHE | P22303 | 2/20 | 0.40 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15712191 | 0.91 | HTR7 (0.54) | HTR7CYP19A1ALDH1A1NPC1POLB | |
| SCHEMBL7805941 | 0.88 | HTR7 (0.53) | HTR7SIGMAR1ACHEMEN1KMT2A | |
| SCHEMBL31324652 | 0.84 | HTR7 (0.54) | HTR7SIGMAR1ACHEMAPT | |
| SCHEMBL3354696 | 0.84 | HTR7 (0.58) | HTR7SIGMAR1ACHECYP19A1ALDH1A1 | |
| SCHEMBL3357957 | 0.82 | HTR7 (0.63) | HTR7SIGMAR1ACHEALDH1A1PKM | |
| SCHEMBL7805916 | 0.82 | BRD4 (0.43) | HTR7SIGMAR1ACHEMEN1KMT2A | |
| SCHEMBL7805698 | 0.81 | HTR7 (0.45) | HTR7SIGMAR1ACHEALDH1A1NPC1 | |
| SCHEMBL7804089 | 0.81 | HTR7 (0.44) | HTR7SIGMAR1ACHEMEN1KMT2A | |
| SCHEMBL7807013 | 0.80 | HTR7 (0.43) | HTR7SIGMAR1ACHEMEN1KMT2A | |
| SCHEMBL7798296 | 0.77 | HTR7 (0.40) | HTR7ACHEKDM2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0902027-B1 | Indole and indazole derivatives, process for their preparation and the pharmaceutical compositions containing them | ADIR (FR) | 2001-07-25 | — | — | EP | disclosed |
| US-6046205-A | FOR TREATMENT OF VENOUS INSUFFICIENCY AND OF ASSOCIATED DISORDERS, AND ALSO IN THE TREATMENT OF MIGRAINE | ADIR ET COMPAGNIE (FR) | 2000-04-04 | — | — | US | disclosed |
| EP-0902027-A1 | Indole and indazole derivatives, process for their preparation and the pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1999-03-17 | — | — | EP | disclosed |