Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR7 | P34969 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | CFTR | P13569 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | BRD4 | O60885 | 1/20 | 0.39 |
| ▸ | ACHE | P22303 | 1/20 | 0.39 |
| ▸ | DRD4 | P21917 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.38 |
| ▸ | CDC7 | O00311 | 1/20 | 0.37 |
| ▸ | HRH1 | P35367 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7805913 | 0.86 | NPC1 (0.43) | KDM4EALDH1A1CFTRSMN1; SMN2L3MBTL1 | |
| SCHEMBL917196 | 0.82 | BRD4 (0.51) | HTR7KDM4EALDH1A1CFTRSMN1; SMN2 | |
| SCHEMBL7806978 | 0.82 | KDM4E (0.47) | HTR7KDM4EALDH1A1CFTRSMN1; SMN2 | |
| SCHEMBL7804893 | 0.81 | HTR7 (0.54) | HTR7KDM4EALDH1A1CFTRBRD4 | |
| SCHEMBL7805941 | 0.81 | HTR7 (0.53) | HTR7KDM4EALDH1A1ACHEMEN1 | |
| SCHEMBL7804089 | 0.80 | HTR7 (0.44) | HTR7ALDH1A1CFTRSMN1; SMN2ACHE | |
| SCHEMBL7804121 | 0.80 | HTR1D (0.44) | KDM4EALDH1A1SMN1; SMN2L3MBTL1BRD4 | |
| SCHEMBL7808340 | 0.80 | HTR7 (0.52) | HTR7KDM4EALDH1A1SMN1; SMN2ACHE | |
| SCHEMBL7804919 | 0.79 | KDM4E (0.41) | KDM4EALDH1A1SMN1; SMN2L3MBTL1BRD4 | |
| Hydrochloric Acid SCHEMBL8031546 | 0.79 | HTR1D (0.44) | KDM4EALDH1A1SMN1; SMN2L3MBTL1BRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0902027-B1 | Indole and indazole derivatives, process for their preparation and the pharmaceutical compositions containing them | ADIR (FR) | 2001-07-25 | — | — | EP | disclosed |
| US-6046205-A | FOR TREATMENT OF VENOUS INSUFFICIENCY AND OF ASSOCIATED DISORDERS, AND ALSO IN THE TREATMENT OF MIGRAINE | ADIR ET COMPAGNIE (FR) | 2000-04-04 | — | — | US | disclosed |
| US-6020336-A | Indole and indazole compounds | LES LABORATOIRES SERVIER (FR) | 2000-02-01 | — | — | US | disclosed |
| EP-0902027-A1 | Indole and indazole derivatives, process for their preparation and the pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1999-03-17 | — | — | EP | disclosed |