Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR7 | P34969 | 1/20 | 0.44 |
| ▸ | ACHE | P22303 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | CFTR | P13569 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | CRHBP | P24387 | 1/20 | 0.36 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7805941 | 0.81 | HTR7 (0.53) | HTR7ACHEKMT2AMEN1ALDH1A1 | |
| SCHEMBL7808706 | 0.81 | ACHE (0.41) | HTR7ACHEKMT2AMEN1CFTR | |
| SCHEMBL7808340 | 0.81 | HTR7 (0.52) | HTR7ACHEKMT2AMEN1SMN1; SMN2 | |
| SCHEMBL7807013 | 0.80 | HTR7 (0.43) | HTR7ACHEKMT2AMEN1CFTR | |
| SCHEMBL7804076 | 0.79 | HTR1D (0.44) | ALDH1A1SIGMAR1 | |
| Hydrochloric Acid SCHEMBL8031070 | 0.78 | HTR1D (0.44) | SIGMAR1 | |
| SCHEMBL3354696 | 0.78 | HTR7 (0.58) | HTR7ACHEALDH1A1MAPTSIGMAR1 | |
| SCHEMBL31324652 | 0.76 | HTR7 (0.54) | HTR7ACHEMAPTSIGMAR1 | |
| SCHEMBL7804112 | 0.76 | CFTR (0.40) | ACHEKMT2ACFTRSMN1; SMN2ALDH1A1 | |
| SCHEMBL3357957 | 0.74 | HTR7 (0.63) | HTR7ACHEALDH1A1SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0902027-B1 | Indole and indazole derivatives, process for their preparation and the pharmaceutical compositions containing them | ADIR (FR) | 2001-07-25 | — | — | EP | disclosed |
| US-6046205-A | FOR TREATMENT OF VENOUS INSUFFICIENCY AND OF ASSOCIATED DISORDERS, AND ALSO IN THE TREATMENT OF MIGRAINE | ADIR ET COMPAGNIE (FR) | 2000-04-04 | — | — | US | disclosed |
| US-6020336-A | Indole and indazole compounds | LES LABORATOIRES SERVIER (FR) | 2000-02-01 | — | — | US | disclosed |
| EP-0902027-A1 | Indole and indazole derivatives, process for their preparation and the pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1999-03-17 | — | — | EP | disclosed |