Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 4/20 | 0.48 |
| ▸ | DRD3 | P35462 | 4/20 | 0.48 |
| ▸ | DRD4 | P21917 | 3/20 | 0.48 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Maleic Acid SCHEMBL8763115 | 0.90 | DRD2 (0.41) | DRD2DRD3DRD4 | |
| Maleic Acid SCHEMBL8684318 | 0.90 | DRD2 (0.41) | DRD2DRD3DRD4 | |
| SCHEMBL10741006 | 0.76 | NR2E1 (0.47) | DRD2HTR2C | |
| SCHEMBL5265951 | 0.74 | POLB (0.44) | SIGMAR1HTR2C | |
| SCHEMBL9684548 | 0.73 | DRD2 (0.56) | DRD2DRD3DRD4 | |
| SCHEMBL10746073 | 0.73 | HTR2A (0.40) | HTR2C | |
| SCHEMBL10748273 | 0.72 | CNR1 (0.36) | HTR2C | |
| SCHEMBL10743543 | 0.72 | NR2E1 (0.36) | — | |
| SCHEMBL10747577 | 0.72 | NR2E1 (0.31) | — | |
| SCHEMBL10746248 | 0.72 | VPS4B (0.41) | DRD2HTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0613465-B1 | 1,3-SUBSTITUTED CYCLOALKENES AND CYCLOALKANES AS CENTRAL NERVOUS SYSTEM AGENTS | WARNER LAMBERT CO (US) | 2001-10-04 | — | — | EP | disclosed |
| EP-0781274-A1 | IMPROVED PROCESS FOR R (+) 1,2,3,6-TETRAHYDRO-4-PHENYL-1-[(3-PHENYL-3-CYCLOHEXEN-1-YL)METHYL]PYRIDINE, A CENTRAL NERVOUS SYSTEM AGENT | WARNER-LAMBERT COMPANY (US) | 1997-07-02 | — | — | EP | disclosed |
| WO-1996008473-A1 | IMPROVED PROCESS FOR R (+) 1,2,3,6-TETRAHYDRO-4-PHENYL-1-[(3-PHENYL-3-CYCLOHEXEN-1-YL)METHYL]PYRIDINE, A CENTRAL NERVOUS SYSTEM AGENT | WARNER-LAMBERT COMPANY (US) | 1996-03-21 | — | — | WO | disclosed |
| US-5314896-A | Dopaminergic agents, antipsychotic and hypotensive agents | WARNER-LAMBERT COMPANY (US) | 1994-05-24 | — | — | US | disclosed |