Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2BTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3MPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PPARGSLC6A2SLC6A3SLC6A4SMOTYK2pol
The experimentally established mechanism targets of Maleic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 known ✓ | P14416 | 4/20 | 0.41 |
| ▸ | HRH1 known ✓ | P35367 | 1/20 | 0.32 |
| ▸ | DRD3 | P35462 | 4/20 | 0.41 |
| ▸ | DRD4 | P21917 | 3/20 | 0.41 |
| ▸ | F2 | P00734 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Maleic Acid SCHEMBL8684318 | 1.00 | DRD2 (0.41) | DRD2DRD3DRD4F2HRH1 | |
| SCHEMBL7808380 | 0.90 | DRD2 (0.48) | DRD2DRD3DRD4 | |
| Maleic Acid SCHEMBL8762562 | 0.72 | KDM4E (0.44) | DRD2DRD3DRD4ALDH1A1 | |
| Ci-1007 SCHEMBL8763314 | 0.71 | DRD2 (0.82) | DRD2DRD3DRD4 | |
| Ci-1007 SCHEMBL8763325 | 0.71 | DRD2 (0.82) | DRD2DRD3DRD4 | |
| SCHEMBL11512014 | 0.71 | DRD2 (0.52) | DRD2DRD3DRD4ALDH1A1 | |
| SCHEMBL9164706 | 0.70 | GRM5 (0.44) | DRD2ALDH1A1 | |
| SCHEMBL9684548 | 0.69 | DRD2 (0.56) | DRD2DRD3DRD4 | |
| SCHEMBL10741006 | 0.68 | NR2E1 (0.47) | DRD2TAAR1 | |
| SCHEMBL6648243 | 0.67 | SIGMAR1 (0.36) | F2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0781274-A1 | IMPROVED PROCESS FOR R (+) 1,2,3,6-TETRAHYDRO-4-PHENYL-1-[(3-PHENYL-3-CYCLOHEXEN-1-YL)METHYL]PYRIDINE, A CENTRAL NERVOUS SYSTEM AGENT | WARNER-LAMBERT COMPANY (US) | 1997-07-02 | — | — | EP | claimed |
| WO-1996008473-A1 | IMPROVED PROCESS FOR R (+) 1,2,3,6-TETRAHYDRO-4-PHENYL-1-[(3-PHENYL-3-CYCLOHEXEN-1-YL)METHYL]PYRIDINE, A CENTRAL NERVOUS SYSTEM AGENT | WARNER-LAMBERT COMPANY (US) | 1996-03-21 | — | — | WO | claimed |
| EP-0781274-A1 | IMPROVED PROCESS FOR R (+) 1,2,3,6-TETRAHYDRO-4-PHENYL-1-[(3-PHENYL-3-CYCLOHEXEN-1-YL)METHYL]PYRIDINE, A CENTRAL NERVOUS SYSTEM AGENT | WARNER-LAMBERT COMPANY (US) | 1997-07-02 | — | — | EP | disclosed |
| WO-1996008473-A1 | IMPROVED PROCESS FOR R (+) 1,2,3,6-TETRAHYDRO-4-PHENYL-1-[(3-PHENYL-3-CYCLOHEXEN-1-YL)METHYL]PYRIDINE, A CENTRAL NERVOUS SYSTEM AGENT | WARNER-LAMBERT COMPANY (US) | 1996-03-21 | — | — | WO | disclosed |