Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 2/20 | 0.60 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.57 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.57 |
| ▸ | BRD4 | O60885 | 1/20 | 0.52 |
| ▸ | ITGA1 | P56199 | 1/20 | 0.49 |
| ▸ | CA1 | P00915 | 3/20 | 0.48 |
| ▸ | CA2 | P00918 | 3/20 | 0.48 |
| ▸ | CA9 | Q16790 | 3/20 | 0.48 |
| ▸ | CA12 | O43570 | 1/20 | 0.48 |
| ▸ | CA7 | P43166 | 1/20 | 0.48 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.48 |
| ▸ | PARP1 | P09874 | 1/20 | 0.47 |
| ▸ | FLT1 | P17948 | 1/20 | 0.47 |
| ▸ | FLT4 | P35916 | 1/20 | 0.47 |
| ▸ | KDR | P35968 | 1/20 | 0.47 |
| ▸ | CCR9 | P51686 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3838580 | 0.84 | PARP1 (0.63) | BRD4PARP1 | |
| SCHEMBL2156042 | 0.83 | AKR1C3 (0.59) | AKR1C3AKR1C2CA1CA2CCR9 | |
| SCHEMBL2280385 | 0.83 | PTGS2 (0.56) | PTGS2AKR1C3AKR1C2CA1CA2 | |
| SCHEMBL7810505 | 0.82 | CNR2 (0.50) | CA1CA2CA9PARP1 | |
| SCHEMBL3838117 | 0.81 | PARP1 (0.59) | AKR1C3BRD4ITGA1PARP1 | |
| SCHEMBL6583952 | 0.81 | PTGS2 (0.65) | PTGS2AKR1C3AKR1C2CA1CA2 | |
| SCHEMBL7802286 | 0.81 | ADORA3 (0.61) | PTGS2AKR1C3AKR1C2CA1CA2 | |
| SCHEMBL7810450 | 0.81 | PTGS2 (0.58) | PTGS2AKR1C3CA1CA2CA9 | |
| SCHEMBL241785 | 0.80 | PARP1 (0.68) | PARP1 | |
| SCHEMBL30153175 | 0.80 | PARP1 (0.68) | PARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0891345-B1 | NOVEL FURAN DIARYLMETHYLIDENE DERIVATIVES, METHOD FOR THEIR PREPARATION AND THERAPEUTICAL USES THEREOF | UNION PHARMA SCIENT APPL (FR) | 2001-08-16 | — | — | EP | disclosed |
| WO-2000014082-A1 | DIARYLMETHYLIDENE FURAN DERIVATIVES AS DRUGS WITH ANTI-INFLAMMATORY, ANALGESIC AND CHEMOPREVENTIVE PROPERTIES | LABORATORIES UPSA (FR) | 2000-03-16 | — | — | WO | disclosed |
| EP-0891345-A1 | NOVEL FURAN DIARYLMETHYLIDENE DERIVATIVES, METHOD FOR THEIR PREPARATION AND THERAPEUTICAL USES THEREOF | LABORATOIRES UPSA (FR) | 1999-01-20 | — | — | EP | disclosed |
| US-5807873-A | Diarylmethylidenefuran derivatives and their uses in therapeutics | LABORATORIES UPSA (FR) | 1998-09-15 | — | — | US | disclosed |
| WO-1997037984-A1 | NOVEL FURAN DIARYLMETHYLIDENE DERIVATIVES, METHOD FOR THEIR PREPARATION AND THERAPEUTICAL USES THEREOF | LABORATOIRES UPSA (FR) | 1997-10-16 | — | — | WO | disclosed |