SCHEMBL780873

SCHEMBL780873

c1ccc(-c2cccc(-c3cccc4c3sc3c(-c5ccc6c(c5)c5cc(-c7cccc8c7sc7c(-c9cccc(-c%10ccccc%10)c9)cccc78)ccc5n6-c5ccc(-c6c7ccccc7c(-c7ccccc7)c7ccccc67)cc5)cccc34)c2)cc1

nearest known ligand 0.38

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
ALOX5 P09917 1/20 0.38
KDM4E B2RXH2 1/20 0.34
ATM Q13315 1/20 0.34
L3MBTL1 Q9Y468 1/20 0.34
LIMK1 P53667 1/20 0.34
KMT2A Q03164 1/20 0.33
PRKDC P78527 2/20 0.32
TSPO P30536 1/20 0.31
HDAC4 P56524 1/20 0.31
PIM1 P11309 1/20 0.31
PIM3 Q86V86 1/20 0.31
MAP3K8 P41279 3/20 0.31
ALK Q9UM73 1/20 0.30
PDE10A Q9Y233 1/20 0.30
S1PR4 O95977 1/20 0.30
S1PR5 Q9H228 1/20 0.30
MAPK1 P28482 1/20 0.30
MAP2K1 Q02750 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL780861 0.98 KDM4E (0.39) ALOX5KDM4EATML3MBTL1LIMK1
SCHEMBL781280 0.96 ALOX5 (0.39) ALOX5KDM4EATML3MBTL1LIMK1
SCHEMBL780973 0.95 ALOX5 (0.36) ALOX5KDM4EATML3MBTL1LIMK1
SCHEMBL780673 0.95 ALOX5 (0.39) ALOX5KDM4EATML3MBTL1LIMK1
SCHEMBL781229 0.94 KDM4E (0.40) ALOX5KDM4EATML3MBTL1LIMK1
SCHEMBL781264 0.93 ALOX5 (0.48) ALOX5KDM4EATML3MBTL1LIMK1
SCHEMBL781000 0.93 KDM4E (0.37) ALOX5KDM4EATML3MBTL1LIMK1
SCHEMBL458003 0.93 L3MBTL1 (0.41) ALOX5KDM4EATML3MBTL1LIMK1
SCHEMBL15630503 0.92 ALOX5 (0.41) ALOX5KDM4EATML3MBTL1LIMK1
SCHEMBL780920 0.92 ALOX5 (0.49) ALOX5KDM4EATML3MBTL1LIMK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20160380211-A1 Carbazole Derivative, Light-Emitting Element Material and Organic Semiconductor Material SEMICONDUCTOR ENERGY LABORATORY CO., LTD. (JP) 2016-12-29 US disclosed
US-9450188-B2 Carbazole derivative, light-emitting element material and organic semiconductor material SEMICONDUCTOR ENERGY LABORATORY CO., LTD. (JP) 2016-09-20 US disclosed
US-9450188-B2 Carbazole derivative, light-emitting element material and organic semiconductor material SEMICONDUCTOR ENERGY LABORATORY CO., LTD. (JP) 2016-09-20 US disclosed
US-20140145175-A1 Carbazole Derivative, Light-Emitting Element Material and Organic Semiconductor Material SEMICONDUCTOR ENERGY LABORATORY CO., LTD. (JP) 2014-05-29 US disclosed
US-20140145175-A1 Carbazole Derivative, Light-Emitting Element Material and Organic Semiconductor Material SEMICONDUCTOR ENERGY LABORATORY CO., LTD. (JP) 2014-05-29 US disclosed
US-8642782-B2 Carbazole derivative, light-emitting element material and organic semiconductor material SEMICONDUCTOR ENERGY LABORATORY CO., LTD. (JP) 2014-02-04 US disclosed
US-8642782-B2 Carbazole derivative, light-emitting element material and organic semiconductor material SEMICONDUCTOR ENERGY LABORATORY CO., LTD. (JP) 2014-02-04 US disclosed
US-20120071668-A1 Carbazole Derivative, Light-Emitting Element Material and Organic Semiconductor Material SEMICONDUCTOR ENERGY LABORATORY CO., LTD. 2012-03-22 US disclosed
US-20120071668-A1 Carbazole Derivative, Light-Emitting Element Material and Organic Semiconductor Material SEMICONDUCTOR ENERGY LABORATORY CO., LTD. 2012-03-22 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20160380211-A1 Carbazole Derivative, Light-Emitting Element Material and Organic Semiconductor Material SLC39A3, SULT1A1, NUTF2 ALOX5 1162/4885KDM4E 3917/4885ATM 2271/4885
US-20120071668-A1 Carbazole Derivative, Light-Emitting Element Material and Organic Semiconductor Material SLC39A3, SULT1A1, NUTF2 ALOX5 1162/4885KDM4E 3917/4885ATM 2271/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.